Skip to main content
. 2020 Feb 14;9(1):1725355. doi: 10.1080/2162402X.2020.1725355

Figure 1.

Figure 1.

S100A4 expression is associated with fibrosis-related HCC. (a) Immunohistochemical staining of S100A4 in 75 HCC tissues and 75 adjacent cancer-free tissues in a tissue array was performed. (a) Representative S100A4 staining is shown. (b) Percentage of the cases expressing S100A4 in carcinoma tissues. (c) Average tumor size in HCC patients with different S100A4 protein levels. * P < .05. (d) Percentage of tissues with negative, low and high S100A4 expression with different tumor grades. (e) Serum S100A4 levels in healthy donors (n = 20) and HCC patients (n = 20) were detected by ELISA. *** P < .001. (f) Immunohistochemical staining including H&E, S100A4 and Sirius Red staining of adjacent tissue sections of human HCC tissues. (g) S100A4 expression in mouse models of HCC. Adjacent sections of HCC tissues were stained for S100A4, Sirius Red and ER-TR7 in C57BL/6 mice treated with DEN for 8 months, C57BL/6 mice treated with DEN and CCl4 for 8 months, and C57BL/6 mice treated with DEN and anti-CD137 agonist antibody (2A) for 8 months. Scale bar, 100 μm.