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Figure 3. Solution structure of human p53 DNA binding domain (PDB: 2FEJ) (A-C) and mouse PrP C-terminal domain (PDB: 1AG2) (DandE) with aggregation hot spots predicted by Aggrescan (A), Tango (BandD), and Waltz (C and E). AGGRESCAN hot spots predicted for mouse PrP are located at the N-terminal domain not represented by this model.
