Fig. 1.
Schedule of enrolment, interventions and assessments * Patients receiving twice-weekly haemodialysis sessions are switched to the conventional arm if KrU < 2.5 mL/min/1.73 m2 in two determinations made in a 2-week interval, or if they develop uncontrolled hypertension, heart failure or a clinical event that indicates that the number of haemodialysis sessions should be increased. BNP brain-derived natriuretic peptide, CRP C-reactive protein, HD haemodialysis, KDQOL-SF Kidney Disease Quality of Life Short Form, KrCr creatinine clearance rate, KrU urea clearance rate, PTH parathyroid hormone