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. 2020 Dec 13;69(3):342–354. doi: 10.2337/db19-0281

Figure 5.

Figure 5

Pancreas LDs are rarely found in the aging mouse or in rodent models of hyperlipidemia and hyperglycemia. BODIPY+ (green) LDs are rarely detected in the pancreas of 1.5-year-old (1.5yr) C57BL6 mice, C57BL6 mice fed a low-fat diet (LFD) or HFD, and LDLR−/− mice (top) or SD rats, ZDF rats, control db/+ mice, and diabetic db/db mice (bottom). BODIPY staining of the 35-year-old human donor is shown for comparison (top left). Scale bar = 50 μm. The physiological conditions of the rodents prior to islet isolation are provided in Supplementary Fig. 1. 10wk, 10 weeks old.