Scheme 2.
Synthesis of 3′-aminocombretastatin A-4 (AmCA-4) derivatives. Reagents and conditions: (a) N-Fmoc-l-amino acid or N-Fmoc-d-amino acid, DCC, HOBt and DMF, RT 16 h. (b) KF, 18-crown-6 and DMF, RT 4 h.
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