Table 1.
Relative Abundance of Several GABAergic Neuron Subtypes in ThraAMI/gn, Compared with Control, Mouse Brains at PND14, as Evidenced by Immunohistochemistry
| Cortex |
Hippocampus (DG) |
Hippocampus (CA) |
Striatum |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | ThraAMI/gn | Control | ThraAMI/gn | Control | ThraAMI/gn | Control | ThraAMI/gn | ||
| Parvalbumin neuronal density | Mean | 1.00 | 0.05a | 1.00 | 0.05a | 1.00 | 0.33a | 1.00 | 0.10a |
| SD | 0.14 | 0.01 | 0.50 | 0.13 | 0.34 | 0.21 | 0.48 | 0.15 | |
| n | 11 | 10 | 11 | 12 | 11 | 10 | 10 | 8 | |
| Neuropeptide Y neuronal density | Mean | 1.00 | 0.58a | 1.00 | 0.92 | ND | ND | 1.00 | 1.07 |
| SD | 0.00 | 0.11 | 0.00 | 0.06 | ND | ND | 0.11 | 0.20 | |
| n | 5 | 6 | 3 | 3 | ND | ND | 5 | 6 | |
| Neuropeptide Y fluorescence intensity | Mean | ND | ND | 1.00 | 1.23a | ND | ND | 1.00 | 1.31a |
| SD | ND | ND | 0.00 | 0.08 | ND | ND | 0.06 | 0.25 | |
| n | ND | ND | 3 | 3 | ND | ND | 6 | 6 | |
| Calretinin neuronal density | Mean | 1.00 | 0.75 | ND | ND | 1.00 | 4.90a | ND | ND |
| SD | 0.12 | 0.54 | ND | ND | 0.41 | 4.10 | ND | ND | |
| n | 5 | 4 | ND | ND | 5 | 4 | ND | ND | |
| Somatostatin neuronal density | Mean | 1.00 | 1.12 | 1.00 | 2.55a | 1.00 | 1.08 | 1.00 | 1.16 |
| SD | 0.02 | 0.31 | 0.14 | 0.66 | 0.13 | 0.29 | 0.03 | 0.19 | |
| n | 6 | 5 | 6 | 5 | 6 | 5 | 6 | 5 | |
See also Table S1.
a
Significantly different from control (p < 0.05).