Table 1. Comparison of clinical characteristics and basic laboratory tests between the two groups.
| IMN (N = 229) | APLA2R-ab(-)(N = 59) | APLA2R-ab +(N = 170) | P value | |
|---|---|---|---|---|
| Age (year) | 45.88 ± 13.64 | 45.75 ± 13.49 | 45.92 ± 13.73 | 0.931 |
| Sex (female (%)) | 91/229 (39.74%) | 30/59 (50.84%) | 61/170 (35.88%) | 0.043* |
| Duration of illness (day) | 117.72 ± 175.40 | 129.57 ± 210.58 | 112.44 ± 160.84 | 0.542 |
| SBP (mmHg) | 137.70 ± 20.48 | 135.63 ± 23.30 | 140.90 ± 21.03 | 0.190 |
| DBP (mmHg) | 87.10 ± 13.89 | 88.93 ± 16.66 | 88.08 ± 13.93 | 0.626 |
| Urine RBC/HPF | 14.07 ± 17.76 | 11.24 ± 14.87 | 15.04 ± 18.59 | 0.160 |
| 24HUPRO (g/L) | 6.12 ± 8.17 | 4.91 ± 3.18 | 5.81 ± 3.50 | 0.086 |
| WBC (×109/L) | 8.28 ± 17.76 | 11.95 ± 34.47 | 7.00 ± 2.81 | 0.275 |
| HGB (g/L) | 134.28 ± 30.47 | 132.18 ± 38.80 | 135.01 ± 27.05 | 0.605 |
| PLT (×109/L) | 268.09 ± 71.73 | 270.17 ± 95.40 | 267.36 ± 61.64 | 0.833 |
| AST (u/L) | 22.67 ± 8.20 | 23.26 ± 8.61 | 22.46 ± 8.07 | 0.525 |
| ALT (u/L) | 22.83 ± 11.96 | 25.37 ± 12.18 | 21.96 ± 11.79 | 0.063 |
| SOD (u/mL) | 111.83 ± 27.18 | 115.83 ± 28.70 | 110.41 ± 26.59 | 0.245 |
| TP (g/L) | 47.53 ± 7.60 | 49.17 ± 8.28 | 46.97 ± 7.30 | 0.056 |
| ALB (g/L) | 24.69 ± 5.42 | 26.11 ± 6.02 | 24.20 ± 5.11 | 0.019* |
| GLO (g/L) | 22.92 ± 4.61 | 23.62 ± 4.67 | 22.68 ± 4.58 | 0.183 |
| GLU (mmol/L) | 5.36 ± 1.30 | 5.59 ± 1.99 | 5.28 ± 0.93 | 0.248 |
| BUN (mmol/L) | 5.36 ± 1.92 | 5.44 ± 1.93 | 5.33 ± 1.93 | 0.702 |
| CREA (μmol/L) | 64.78 ± 15.78 | 61.57 ± 15.88 | 65.90 ± 15.64 | 0.033* |
| Cys-C(mg/L) | 0.99 ± 0.48 | 1.06 ± 0.81 | 0.97 ± 0.28 | 0.427 |
| BMG (mg/L) | 2.32 ± 0.80 | 2.13 ± 0.74 | 2.39 ± 0.81 | 0.045* |
| RBP (mg/L) | 55.97 ± 18.24 | 54.36 ± 16.44 | 56.51 ± 18.83 | 0.451 |
| Ca (mmol/L) | 2.17 ± 0.21 | 2.17 ± 0.21 | 2.17 ± 0.22 | 0.972 |
| CHOL (mmol/L) | 8.84 ± 2.68 | 8.62 ± 2.68 | 8.92 ± 2.69 | 0.485 |
| HDL-C (mmol/L) | 1.66 ± 0.51 | 1.71 ± 0.60 | 1.65 ± 0.48 | 0.454 |
| LDL-C (mmol/L) | 5.45 ± 2.25 | 5.14 ± 1.95 | 5.56 ± 2.34 | 0.243 |
| FSGS | 41/229 (17.9%) | 9/59(15.25%) | 32/170 (18.82%) | 0.538 |
| IgG4 (mg/L) | 352.49 ± 317.78 | 305.83 ± 268.24 | 368.56 ± 332.43 | 0.220 |
| IgG (g/L) | 5.74 ± 2.51 | 5.71 ± 2.27 | 5.74 ± 2.59 | 0.942 |
| IgM (g/L) | 1.13 ± 0.51 | 1.17 ± 0.53 | 1.11 ± 0.50 | 0.449 |
| IgA (g/L) | 2.34 ± 0.91 | 2.24 ± 0.86 | 2.37 ± 0. 86 | 0.360 |
| C3 (g/L) | 1.19 ± 0.23 | 1.19 ± 0.18 | 1.18 ± 0.24 | 0.937 |
| C4 (g/L) | 0.30 ± 0.08 | 0.28 ± 0.07 | 0.30 ± 0.18 | 0.112 |
| C1q (mg/L) | 216.70 ± 38.59 | 213.19 ± 34.61 | 217.99 ± 40.01 | 0.463 |
Notes.
- SBP
- systolic blood pressure
- DBP
- diastolic blood pressure
- 24HUPRO
- 24-hour urine
- WBC
- white blood cells
- PLT
- platelets
- HGB
- hemoglobin
- AST
- alanine aminotransferase
- SOD
- superoxide dismutase
- TP
- serum total protein
- ALB
- albumin
- GLO
- globulin
- GLU
- blood glucose
- BUN
- blood urea nitrogen
- CREA
- serum creatinine
- Cys-C
- cystatin C
- BMG
- β2 macroglobulin
- RBP
- retinol binding protein
- CHOL
- total cholesterol
- HDL-C
- high-density lipoprotein
- LDL-C
- low-density lipoprotein
- FSGS
- focal glomerular sclerosis
- IgG4
- immunoglobulin G4
- IgG
- immunoglobulin G
- IgM
- immunoglobulin M
- IgA
- immunoglobulin A
- C3 C4
- complement 3 complement 4
- PLA2R
- phospholipase A2 receptors
Compared with the PLa2R− group and the PLA2R+ group, P∗ < 0.05, P∗∗ < 0.01.