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miR-22 inhibits cell apoptosis via targeting PUMA. PC12 cells were transfected with PUMA siRNA or/and anti-miR-22 or its controls then subjected to I/R as the methods in the ‘Materials and methods’ section. (a) PUMA and cleaved-caspase-3 protein expression was detected by Western blot assay; (b, c) Representative TUNEL staining in control and I/R groups; (d) The quantitative analysis of cell apoptosis in control and I/R groups, *p < 0.05; **p < 0.01.
