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. 2020 Feb 4;323(5):444–454. doi: 10.1001/jama.2019.21834

Table 1. Suicides Among People With and Without Neurological Disorders.

With Neurological Disorder No Neurological Disorder Adjusted Incidence
Rate Ratio (95% CI)b
Fully Adjusted Incidence
Rate Ratio (95% CI)c
No./Total No. of Individualsa Incidence Rate per 100 000 Person-Years No./Total No. of Individualsa Incidence Rate per 100 000 Person-Years
Any neurological disorder 5511/1 248 262 44.0 29 972/6 052 133 20.1 2.5 (2.4-2.6) 1.8 (1.7-1.8)
ALS 34/7204 130.8 35 449/7 293 191 21.9 5.1 (3.7-7.2) 4.9 (3.5-6.9)
Huntington disease 19/1228 203.6 35 464/7 299 167 21.9 9.5 (6.1-14.9) 4.9 (3.1-7.7)
Guillain-Barréd 10/3203 36.1 16 060/6 427 797 15.6 2.1 (1.1-3.9) 2.2 (1.2-4.1)
Multiple sclerosis 152/31 136 38.3 35 331/7 269 259 21.9 2.1 (1.8-2.5) 2.2 (1.9-2.6)
Diseases of myoneural junction and muscle 961/129 326 48.6 34 522/7 171 069 21.6 2.7 (2.5-2.9) 1.9 (1.8-2.1)
Other brain disordersd 148/61 354 27.9 15 922/6 369 646 15.6 2.3 (2.0-2.7) 1.8 (1.5-2.1)
Encephalitis 53/9369 39.7 35 430/7 291 026 21.9 2.1 (1.6-2.7) 1.7 (1.3-2.3)
Polyneuropathy and peripheral neuropathy 860/142 073 52.8 34 623/7 158 322 21.6 2.3 (2.1-2.5) 1.7 (1.6-1.8)
Parkinson disease 192/50 262 72.0 35 291/7 250 133 21.8 2.4 (2.1-2.7) 1.7 (1.5-1.9)
Epilepsy 1048/181 686 48.7 34 435/7 118 709 21.6 2.8 (2.6-3.0) 1.7 (1.6-1.8)
Head injury 1592/406 956 36.4 33 891/6 893 439 21.5 2.6 (2.5-2.7) 1.7 (1.6-1.7)
CNS infection 117/30 802 32.1 35 366/7 269 593 21.9 1.9 (1.5-2.2) 1.6 (1.3-1.9)
Meningitis 57/19 317 25.2 35 426/7 281 078 21.9 1.6 (1.2-2.0) 1.6 (1.2-2.0)
Myasthenia gravis 14/6313 26.0 35 469/7 294 082 21.9 1.4 (0.8-2.4) 1.4 (0.8-2.4)
Chronic inflammatory demyelinating polyneuropathyd 4/1798 31.1 16 066/6 429 202 15.6 1.6 (0.6-4.3) 1.4 (0.5-3.7)
Intracerebral hemorrhage 106/28 691 61.1 35 377/7 271 704 21.9 2.1 (1.7-2.6) 1.4 (1.1-1.6)
Cerebral infarction 111/30 240 63.8 35 372/7 270 155 21.9 2.2 (1.8-2.6) 1.3 (1.1-1.6)
Subarachnoid hemorrhage 71/14 953 40.4 35 412/7 285 442 21.9 1.8 (1.4-2.2) 1.3 (1.0-1.7)
Stroke 1235/319 122 56.7 34 248/6 981 273 21.4 1.8 (1.7-1.9) 1.3 (1.2-1.3)
Dementia 569/243 022 57.7 34 914/7 057 373 21.7 2.2 (2.1-2.4) 0.8 (0.7-0.9)
Muscular dystrophy 5/4882 10.2 35 478/7 295 513 21.9 0.6 (0.3-1.5) 0.7 (0.3-1.7)
Intellectual disabilities 96/35 266 23.0 35 387/7 265 129 21.9 1.6 (1.3-1.9) 0.6 (0.5-0.8)
Alzheimer diseased 45/73 279 16.5 16 025/6 357 721 15.6 0.7 (0.5-1.0) 0.2 (0.2-0.3)

Abbreviations: ALS, amyotrophic lateral sclerosis; CNS, central nervous system.

a

Each person could be diagnosed with multiple neurological disorders. The sum of numbers of persons diagnosed with individual disorders is therefore not equal to the number of persons diagnosed any with neurological disorders.

b

Adjusted for period, sex, age group.

c

Full adjusted models were adjusted for period, sex, age group, living status, region, socioeconomic status, physical comorbidity, psychiatric hospitalization prior to diagnosis of any neurological disorders, and deliberate self-harm prior to diagnosis of any neurological disorders.

d

Guillain-Barré, chronic inflammatory demyelinating polyneuropathy, other brain disorders, and Alzheimer disease were only defined in the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision. These analyses were therefore restricted to the 1994-2014 period.