Figure 3.

Resident Immune Cells within Liver. The liver is home to cells with a diversity of immunologic functions. Antigens from systemic and portal circulation are carried into the sinusoids where they are met by resident KCs, lymphocytes, dendritic cells, and HSCs. LSECs line the sinusoids and can also present antigens to activate the immune system. Within the sinusoids are fenestrations where antigens can extrude into the Space of Disse and also through which hepatocytes can sample antigens within sinusoidal lumen. Lymphocytes also reside within the parenchyma amongst hepatocytes. Adapted from with permission from Crispe, Nat Rev Immunol, 2003;3(1):51–62.