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Breast Cancer Research : BCR logoLink to Breast Cancer Research : BCR
. 2020 Feb 26;22:25. doi: 10.1186/s13058-020-01259-w

Correction to: Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers

Nasim Mavaddat 1,, Antonis C Antoniou 1, Thea M Mooij 2, Maartje J Hooning 3, Bernadette A Heemskerk-Gerritsen 3; GENEPSO4, Catherine Noguès 4, Marion Gauthier-Villars 5, Olivier Caron 6, Paul Gesta 7, Pascal Pujol 8, Alain Lortholary 9; EMBRACE1, Daniel Barrowdale 1, Debra Frost 1, D Gareth Evans 10, Louise Izatt 11, Julian Adlard 12, Ros Eeles 13, Carole Brewer 14, Marc Tischkowitz 15, Alex Henderson 16, Jackie Cook 17, Diana Eccles 18; HEBON19, Klaartje van Engelen 20, Marian J E Mourits 21, Margreet G E M Ausems 22, Linetta B Koppert 23, John L Hopper 24, Esther M John 25, Wendy K Chung 26,27, Irene L Andrulis 28,29, Mary B Daly 30, Saundra S Buys 31; kConFab Investigators32,33, Javier Benitez 34, Trinidad Caldes 35, Anna Jakubowska 36,37, Jacques Simard 38, Christian F Singer 39, Yen Tan 39, Edith Olah 40, Marie Navratilova 41, Lenka Foretova 41, Anne-Marie Gerdes 42, Marie-José Roos-Blom 2, Flora E Van Leeuwen 2, Brita Arver 43,44, Håkan Olsson 44, Rita K Schmutzler 45,46, Christoph Engel 47, Karin Kast 48,49,50, Kelly-Anne Phillips 24,33,51, Mary Beth Terry 52,27, Roger L Milne 24,53,54, David E Goldgar 55, Matti A Rookus 2, Nadine Andrieu 56,57,58,59,#, Douglas F Easton 1,60,#; on behalf of IBCCS, kConFab and BCFR
PMCID: PMC7045606  PMID: 32102695

Correction to: Breast Cancer Res

https://doi.org/10.1186/s13058-020-1247-4

After publication of the original article [1], we were notified that columns in Table 2 were erroneously displayed.

The correction version of Table 2 is shown below.

Table 2.

Characteristics of cohort of BRCA1 and BRCA2 mutation carriers

BRCA1 mutation carriers BRCA2 mutation carriers
Unaffected women (N = 2003) Women with breast cancer (N = 269) Unaffected women (N = 1448) Women with breast cancer (N = 157)
Total Person-years of follow-up 11,207 1134 7286 600
Person-years of follow-up (mean (sd)) 5.60 (3.67) 4.21 (3.27) 5.03 (3.44) 3.82 (3.08)
Age at start of follow-up (mean (sd)) 37.51 (11.80) 40.68 (10.25) 40.00 (12.53) 45.14 (10.11)
Age at diagnosis/censoring (mean (sd)) 43.10 (12.28) 44.90 (10.33) 45.00 (13.00) 48.97 (10.30)
Reason for censoring
 Breast cancer 0 269 0 157
 Ovarian cancer 49 3a 9 1a
 Other cancer 45 5a 28 2a
 RRM 299 181
 Death 5 8
 Unaffected at last follow-up time 1605 1222
Year of birth
 < =1960 604 (83.54) 119 (16.46) 500 (84.75) 90 (15.25)
 > 1960 1399 (90.32) 150 (9.68) 948 (93.40) 67 (6.60)
Menopausal status
 Premenopausal at censoringb
  Last informationc after censoring 512 69 344 35
  Last information before censoringd 585 58 473 35
 Postmenopausal
  Natural menopause age known 194 27 182 31
  Natural menopause age unknown 5 0 7 1
 Post hysterectomy 70 12 64 11
  Unknown menopausal status 62 13 33 8
RRSO status at censoring
 No RRSO
  Last information after censoring 664 110 467 79
  Last information before censoring 618 44 535 27
 RRSO 721 115 446 51
  As reason for menopausee 574 90 345 36
  After natural menopause 101 18 76 10
  After hysterectomy 46 7 25 5

Abbreviations: RRSO Risk-Reducing Salpingo-oophorectomy, RRM Risk Reducing Mastectomy

aDiagnosed at the same time as breast cancer

bFifteen women did not report age at menopause but were older than 60 years at the end of follow-up

cInformation from questionnaire and record linkage

dAge last known to be premenopausal: mean 32.3 years, median 31 years for BRCA1 mutation carriers: mean 33.9, median 34 years for BRCA2 mutation carriers. Time between this age and end of censoring: mean 6.3, median 5 years for BRCA1 and mean 6 years, median 5 years for BRCA2 mutation carriers

eSeven women reported RRSO after age 60 years without first reporting natural menopause

Footnotes

Nadine Andrieu and Douglas F. Easton contributed equally to this work.

Reference

  • 1.Mavaddat, et al. Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers. Breast Cancer Res. 2020;22:8. doi: 10.1186/s13058-020-1247-4. [DOI] [PMC free article] [PubMed] [Google Scholar]

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