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Summary of Functional Characteristics of Four Mutants
| Genotypes | Mutant proteins | T3 binding | Transcription activity | Dominant negative activity |
|---|---|---|---|---|
| thraa 4-bp deletion | ThraaPhe404Leufs*22 | No | No | Yes |
| thraa 8-bp insertion | ThraaLeu405Glufs*6 | No | No | Yes |
| thrab 1-bp insertion | ThrabGlu394* | No | No | Yes |
| thrab 4-bp deletion | ThrabThr393Profs*31 | Yes | Yes | No |
T3, triiodothyronine.
