Correction to: Pharm Res
10.1007/s11095-019-2727-z
There was a mistake in the unit of clearance (Cl) in Table II. In addition, the descriptions of V1(ROL) and V1(GRMS-55) were imprecise and the reference number in the footnote below this table should be (9). The corrected Table appears below.
Table II.
Values of Pharmacokinetic Parameters of (±)-LSF, GRMS-55, Rolipram, and PTX as a Metabolite in Female Lewis and Male Wistar Rats
| Rolipram | GRMS-55 | (±)-LSF | ||||||
|---|---|---|---|---|---|---|---|---|
| Parameter | Brief description | Estimate (CV%) | Parameter | Brief description | Estimate (CV%) | Parameter | Brief description | Estimate (CV%) |
| Female Lewis rats | ||||||||
| V(ROL)/F (L kg−1) | Volume of distribution divided by fraction absorbed | 1.02 (2.9) | V1(GRMS-55) (L kg−1) | Volume of central compartment | 1.60 (15.4) | VLSF (L kg−1) | Volume of distribution of (±)-LSF | 0.37 (12.5) |
| ka(ROL) (min−1) | Absorption rate constant | 0.228 (15.4) | ka(GRMS-55) (min−1) | Absorption rate constant | 0.045 (17.6) | VPTXm/fm (L kg−1) | Volume of distribution divided by fraction metabolized | 1.95 (21.2) |
| Clt/F(ROL) (L min−1 kg−1) | Apparent total clearance following IP administration | 0.023 (2.1) | Clt(GRMS-55) (L min−1 kg−1) | Total clearance | 0.053 (10.8) | ka(LSF) (min−1) | Absorption rate constant | 0.032 (13.8) |
| Cld(GRMS-55) (L min−1 kg−1) | Distribution clearance | 0.080 (28.6) | kd (min−1) | Overall parent elimination rate constant | 0.212 (27.1) | |||
| V2(GRMS-55) (L kg−1) | Volume of peripheral compartment | 2.14 (29.6) | kem (min−1) | Metabolite elimination rate constant | 0.039 (12.1) | |||
| kconv (min−1) | Conversion rate constant of PTX to (±)-LSF | 0.054 (29.1) | ||||||
| Male Wistar rats | ||||||||
| V1(ROL) (L kg−1) | Volume of central compartment | 0.58 (11.6) | V(GRMS-55) (L kg−1) | Volume of distribution | 1.59 (9.2) | VLSF (L kg−1) | Volume of distribution of (±)-LSF | 1.22 (3.4)a |
| Clt(ROL) (L min−1 kg−1) | Total clearance | 0.037 (2.6) | Clt(GRMS-55) (L min−1 kg−1) | Total clearance | 0.051 (6.4) | VPTXm (L kg−1) | Volume of distribution of PTX | 2.01 (9.5)a |
| Cld(ROL) (L min−1 kg−1) | Distribution clearance | 0.021 (16.0) | Vmax (mg min−1 kg−1) | Maximal elimination rate constant of (±)-LSF | 0.433 (56.9)a | |||
| V2(ROL) (L kg−1) | Volume of peripheral compartment | 0.28 (10.0) | Km (mg L−1) | Michaelis-Menten constant | 6.02 (91.8)a | |||
| km12 (min−1) | Distribution rate constant of PTX | 0.203 (12.7)a | ||||||
| km21 (min−1) | Redistribution rate constant of PTX | 0.095 (12.9)a | ||||||
| kem (min−1) | Elimination rate constant of PTX | 0.116 (9.8)a | ||||||
adata already published (9)
Footnotes
The online version of the original article can be found at 10.1007/s11095-019-2727-z