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. 2020 Mar 3;9:e52420. doi: 10.7554/eLife.52420

Figure 7. GRIP1-dependent increases of sGluA1 following deprivation.

(A–C) Synaptic GluA1 and GRIP1 levels in V1 from WT and Grip1 knockout (KO) mice with 2 days of sham-surgery or VD (n = 5; Student’s t-test and two-way ANOVA). (D–E) Changes in spine sGluA1 expression on apical dendrites of V1 L2/3 neurons from Grip1 KO mice following VD (n = 32 dendrites from five mice; one-way ANOVA). Scale bar: 5 μm. (F) Model of spine GluA1 dynamics in mice with normal experience or visual deprivation. Data are presented as mean ± SEM. n.s., not significant; *p<0.05; ****p<0.0001.

Figure 7.

Figure 7—figure supplement 1. GRIP1-dependent changes in V1 L2/3 neurons following visual deprivation.

Figure 7—figure supplement 1.

(A) Changes in spine sGluA1 following VD in WT mice and Grip1 KO mice (WT-VD: n = 49 dendrites from eight mice; Grip1 KO-VD: n = 32 dendrites from five mice; two-way ANOVA). (B) Changes in spine size following VD in Grip1 KO mice (n = 32 dendrites from five mice; one-way ANOVA). Data are presented as mean ± SEM. *p<0.05; **p<0.01. ***p<0.001. ****p<0.0001.