Fig. 3.

Structural disconnection data. (a) The regional parcels and tractography atlas. (b) Left – Cortical SC matrix derived from the tractography atlas and regional parcels. Right – Cortical SSPL matrix derived from the atlas SC matrix. Atlas SSPL values are integers ranging from 1 to 6. Directly structurally connected regions have SSPLs equal to 1. Cortical regions are organized by hemisphere within each matrix, and the horizontal and vertical black lines on each matrix divide the matrix into quadrants corresponding to intra-LH connections (upper left quadrant), interhemispheric connections (bottom left and upper right quadrants), and intra-RH connections (lower right quadrant). Cortical regions are further organized according to their a priori resting-state network assignments from cortical parcellation as indicated by the colored bars along the edges of each matrix and the legend at the bottom of the figure. The light grey lines extending from the tick marks between these colored bars form “boxes” delineating portions of each matrix corresponding to different sets of within-network (i.e. on-diagonal “boxes” within each quadrant) and between-network (i.e. off-diagonal “boxes” within each quadrant) connections. (c) Lesion segmentation (left) and affected streamlines (right) for a single patient overlaid on that patient’s T2-weighted scan. (d) Left -- spared cortical direct structural connections (red) and direct cortical structural disconnections (black – direct SDC) for the patient shown in (c). Right – spared cortical SSPLs (colored), indirect cortical structural disconnections (gray – indirect SDC), and direct cortical structural disconnections (black– direct SDC) are shown for the same patient shown in (c). Patient SSPLs values are integers ranging from 1 to 6+ (max=infinity, where infinity indicates that no shortest paths exist). The upper left quadrants in the matrices shown in (d) correspond to connections within the contralesional hemisphere, which were spared by the right hemisphere lesion. Note: SSPL calculations also considered cortico-subcortical connections, but these connections are not shown in the matrices above. All brain images are shown in neurological convention (i.e. the left side of the brain is on the left).