Figure 6.

Investigating the behavior of the Ca²⁺ fluxes through IP₃ receptor and CRAC channel. (A) Ca²⁺ fluxes through the IP₃ receptor from Figure 4: control (black), disabled mitochondrial Ca²⁺ uptake (red), blocked SERCA pump (green), and disabled mitochondria and SERCA (blue). (B) Ca²⁺ current for the four cases. (C) The activation of the CRAC channel is controlled by the [Ca²⁺]_ER for the four cases from Figure 4: control (black), disabled mitochondrial Ca²⁺ uptake (red dashed), blocked SERCA pump (green), and disabled mitochondria and SERCA (blue solid). (D) CRAC inactivation is driven by subspace Ca²⁺ concentration.