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. 2019 Dec 26;23(2):171–181. doi: 10.1007/s11102-019-01020-3

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — ROC curves drawn for the calculation of week-12 cut-off values for predicting hormonal control and TV responder status at LVA when a hormonal control is defined as GH ≤ 2.5 µg/L and IGF-1 levels within normal ranges at LVA, b tight hormonal control is defined as GH < 1.0 µg/L and IGF-1 levels within normal ranges at LVA, and c TV responder status is defined as ≤ 20% reduction in TV at LVA. GH growth hormone, IGF-1 insulin-like growth factor-1, LVA last post-baseline value available, ROC receiver operating characteristic, TV tumor volume, ULN upper limit of normal. Data are from the intention-to-treat population for patients with LVA data (n = 88)