Table 3.
Univariate logistic regression analyses for TV responder status
| Number of patients | Odds ratio [95% CI] | p-Value | |
|---|---|---|---|
| Baseline | |||
| Age (per 10-year higher age) | 89 | 1.17 [0.82; 1.66] | 0.380 |
| Sex (women vs men) | 89 | 1.32 [0.56; 3.12] | 0.531 |
| BMI (≥ 25 vs 20–25 kg/m2) | 89 | 0.68 [0.26; 1.73] | 0.413 |
| GH (per 1-μg/L lower level) | 89 | 0.98 [0.95; 1.01] | 0.116 |
| IGF-1 (per 50% ULN lower level) | 89 | 1.02 [0.86; 1.22] | 0.794 |
| TV (per 100-mm3 smaller size) | 89 | 1.00 [0.99; 1.01] | 0.976 |
| Week 12 | |||
| GH (per 1-μg/L lower level) | 85 | 1.12 [1.01; 1.25] | 0.039 |
| IGF-1 (per 50% lower level ULN) | 85 | 1.48 [1.13; 1.94] | 0.004 |
| TV (per 100-mm3 smaller size) | 85 | 1.00 [0.99; 1.02] | 0.491 |
| Change-from-baseline to week 12 | |||
| GH (per 10% increase) | 85 | 0.78 [0.67; 0.90] | < 0.001 |
| IGF-1 (per 10% increase) | 85 | 0.73 [0.62; 0.87] | < 0.001 |
| TV (per 10% reduction) | 85 | 7.15 [3.15; 16.20] | < 0.001 |
BMI body mass index, GH growth hormone, IGF-1 insulin-like growth factor-1, TV tumor volume, ULN upper limit of normal
Factors in bold are statistically significant. Data are based on the number of patients with available data for each factor at each timepoint, and with p-values from Chi squared tests. TV responder status was defined as ≥ 20% reduction in TV from baseline to last post-baseline value available