Biodegradable Polymeric Materials: Synthetic Approach

Abstract

Polymeric materials obtained from petroleum resources are nonbiodegradable. Defying degradation, they damage the environment as a result of their ending up in the landfills. Synthesized biodegradable polymeric materials (BPMs) have received increasing interest owing to the difficulty in procuring reproducibility when using natural polymeric materials. Through the modification of natural polymeric materials or materials via chemical, microbiological, enzyme-mediated, and chemo-enzymatic synthesis, a comprehensive range of variegated BPMs can be reaped. Amended natural polymeric materials such as starch, cellulose, and chitin have enhanced properties, while synthetic BPMs such as PLA, PGA, PCL, PDS, and PLGA are explicitly designed to pursue coveted applications in multifarious domains such as whole diagnostics and therapeutics. Synthesized BPMs can be embedded with tailored characteristics to justify the neoteric entails of mankind.

1. Introduction

Upsurge prevailing in developing countries regarding the ecological detriment due to pollution has stretched to perilous heights as a result of the use of polymeric materials. Similar durability characteristics of this type of polymeric material for varied execution in packaging supplies, structure materials, and basic commodities can remedy disposal snags for traditional petroleum-derived polymers, which are not readily biodegradable. Being resistant to biodegradation, they accumulate in the environment. This is the primary reason for the interest in biodegradable polymeric materials.¹

Biodegradable polymeric materials (BPMs) represent a growing field. Owing to their wide-ranging properties, both synthetic and natural polymeric materials perform a vital and ubiquitous role in everyday life. Having a period of effectiveness, BPMs divulge the phenomenon of biodegradation. It is valuable to distinguish between BPMs on the basis of their origin: native or synthetic. Native BPMs represent the synthesis developed during a long course of evolution in nature, while synthetic BPMs are the result of a mere century of research and development, both resulting in materials possessing tailored characteristics for diverse applications. They include proteins (collagen, gelatin, and albumin), polysaccharides (cellulose, chitin, and alginate), nucleic acids, and lipids, which illustrate totally diverse characteristics reliant on the conditions under which they are used. Synthesized BPMs have received increasing interest owing to the difficulty in obtaining reproducibility when using natural polymeric materials. Although first introduced in the 1980s, synthetic BPMs have been attracting attenention in the last two decades, primarily due to ecological fouling and the realization that our natural resources are finite.¹

As for all synthetic polymeric materials, BPMs can be produced with reproducible quality and indigenous purity with no immunogenicity concerns and can be fabricated into a variety of forms in the required bulk with desired morphology. The aptness to tailor the degradation kinetics and mechanical properties while synthesizing BPMs contributes to their multifarious applications by inducing biocompatibility, making them more predictable with respect to polymers isolated from natural sources.²

BPMs can be devised broadly via either modification of natural polymeric materials or through diversified routes used to synthesize BPMs comprising chemical synthesis, microbiological synthesis, enzyme-mediated synthesis, and chemo-enzymatic synthesis.²

Synthetic BPMs such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactic-co-glycolic acid) (PLGA), poly(butylene succinate) (PBA), polycaprolactone (PCL), poly(ethylene adipate) (PEA), poly(p-dioxanone) (PDS), and their copolymers play an imperative role in clinical applications such as nonviral gene delivery vectors, drug-delivery systems,² resorbable sutures, biosensors, tissue engineering scaffolds, regenerative medicine including implants, and orthopedic fixation devices such as pins, rods, and screws. With respect to the varied applications, research on synthetic BPMs has been focused on the simulation of different biopolymeric materials or polymeric materials with degradable backbones, for instance, polyanhydrides, polycarbonates, and polylactones.

This review focuses on the synthesis methods of BPMs. It also briefly summarizes the applications to heighten future research advances in the field of BPMs.

2. Synthesis Methods for the Preparation of BPMs

2.1. Modification of Natural Polymeric Materials

Being readily biodegradable in nature, polysaccharide polymeric materials such as chitosan, chitin, starch, and cellulose can be modified into new BPMs by coblending.

Natural polymers can be modified via various chemical modifications, in particular, nitration, hydroxylation, sulfonation, acylation, alkylation, phosphorylation, thiolation, xanthation, quaternization, and graft copolymerization, of which graft copolymerization is the most promising approach leading to a wide variety of molecular designs.³

2.1.1. Modification of Chitin and Chitosan

Among several methods, graft copolymerization is an influential method used to enhance the antibacterial, chelating, and complexation properties of chitosan. The grafting of chitin and chitosan by covalently binding a molecule onto the backbone enables the synthesis of functional derivatives.

Chitosan contains two reactive groups that can act as grafting sites: the free amino groups (on deacetylated units of chitin) and the hydroxyl groups (on the C3 and C6 carbons on acetylated and deacetylated units of chitin, respectively) (Figure 1).⁴

Figure 1.

Structures of (a) chitin and (b) chitosan.

Molatlhegi et al.⁴ showed that chitosan-grafted polyacrylamide (CGP) was a better flocculant than pure chitosan (Figure 2). Furthermore, the existence of an extremely high adsorption affinity of CGP toward kaolin surfaces was also demonstrated.

Figure 2.

Synthesis of acrylamide-grafted chitosan.

Dong et al.⁵ formed and stabilized nanometric-sized epichlorohydrin cross-linked chitosan magnetic particles by adding sodium hydroxide to the mixture of chitosan/Fe(II)/Fe(III) dropwise with constant stirring (Figure 3). The hydroxyl groups are preferentially reacted with a cross-linking agent in the presence of iron salts (Fe(II) and Fe(III) ions) in the chitosan solution, suggesting the possible interaction of these ions with the protected amino groups. The protection of amino groups due to weak interaction with iron, resulted in the cross-linking of epichlorohydrin-grafted chitosan with the following:

• (a)–NH₂, in the case of alanine, where the −CH₃ group is poorly reactive,
• (b)–NH₂ and −CH₂OH groups in the case of serine, and
• (c)–NH₂ and −CH₂SH groups in the case of cysteine

Figure 3.

Synthesis of alanine-functionalized epichlorohydrin-grafted magnetic chitosan.

2.1.2. Modification of Starch

The large number of hydroxyl groups on starch molecules provide the active sites for chemical modification. The chemical modification involves introducing various functional groups, such as carboxyl, acetyl, and hydroxypropyl, into starch structure (Figure 4). The properties of modified starch are greatly impacted by the source of starch, reaction conditions, and methods used for its modification. Table 1(6) shows some properties of starch prepared via different modifications.

Figure 4.

Structure of starch.

Table 1. Modifications of Starch and Their Properties^a.

modification	properties
cross-linking	better freeze–thaw
	granule stability
	higher heat
	shear stabilities
	lower swelling power
	decreased solubility
	reduced enthalpy of gelatinization
grafting	better biodegradability
	enhanced stability
	stronger water absorbency
	larger hydrodynamic radius and volume
	film making
esterification	more moisture-resistant and thermoplasticity
	better compatibility
	lower biodegradability and thermal stability
etherification	better thermal stability
	enhanced solubility
	better flowability
	improved permeability
	good strength
oxidization	higher solubility
	better viscosity
	enhanced gelatinization temperature
	better water absorbency
	lower enthalpy value
acidification	better recovery
	enhanced solubility
	lower pasting viscosity
	reduced gelatinization enthalpy
dual	combination of properties

^aReproduced from ref (6) with permission from the Royal Society of Chemistry.

Starch-graft-poly(lactic acid) (SGPLA), starch-graft poly(lactic acid-co-glycolic acid) (SGPLGA), and starch-graft poly(lactic acid-co-glycolic acid-co-e-caprolactam) (SGPLGC) copolymers were yielded through the direct polycondensation of starch with lactic acid, glycolic acid, and e-caprolactam sequentially in aqueous media using stannous chloride (SnCl₂) as the catalyst at 120–170 °C (Figure 5).^7a

Figure 5.

Graft polymerization of starch with lactic acid, glycolic acid, and e-caprolactum.

The synthesis of SGPLA was performed in the presence of NH₃·H₂O with urea as the solvent (Figure 6). The effect of urea and NH₃·H₂O dosage concentration on the graft copolymerization of starch with lactic was obvious. The reason was proposed that the dissolution of starch was boosted because of its hydrogen bond with urea to attain homogeneous conditions and favor the esterification of starch with lactic acid. Being easily available and reaction-friendly, ammonia–water was selected as the catalyst to promote the above reaction. It is found that the grafting degree of starch increases with the increase in the amount of ammonia–water in 12 initial stages, but because it is a reversible reaction, excess ammonia–water could promote the hydrolysis of ester, which would decrease the grafting degree of starch.^7b

Figure 6.

Synthesis of SGPLA.

Misman et al.^7c etherified sago starch by reacting it with benzyl chloride in sodium hydroxide and found that the product resulting from solvent-based etherification had a higher degree of substitution, good thermal stability, and a better ability to flow (Figure 7).

Figure 7.

Etherification of starch.

Sometimes when single modification does not impart the desired properties, further modification is used to meet the requirements for the better application of such a modified starch. Sukhija et al.^7d performed the dual modification of elephant foot yam starch in two different ways to yield modified starches, i.e., oxidized cross-linked starch (OCS) and cross-linked oxidized starch (COS), to check the change in the physiochemical properties because of chemical modification. The oxidation of starch in the presence of sodium hypochlorite (NaOCl) followed by its cross-linking with sodium trimetaphosphate (STMP) (Na₃P₃O₉) produced OCS, whereas the cross-linking of starch with STMP followed by its oxidation through NaOCl yielded COS. OCS possessed improved gel clarity, solubility, and thermal characteristics with respect to COS. The oxidation and cross-linking reactions of starch are shown in Figure 8.

Figure 8.

(a) Oxidation of starch and (b) cross-linking of starch.

2.1.3. Modification of Cellulose

Naturally obtained cellulose can be chemically modified by treating it via esterification, etherification, or deacylation.

Baiardo et al.⁸ modified the surface fibers of cellulose without appreciably altering their native structure and morphology. By the simple esterification and etherification reactions, the high-polarity and high-hydrophilicity properties of natural cellulose fibers were suppressed such that the surface property qualities of the most common thermoplastics are fulfilled. Esterification reactions were carried out using acyl chloride and pyridine, while for performing the etherification of cellulose hydroxyls with ethyl groups, alkylation was carried out in two different alkaline media. Mild reaction conditions were employed in order to maintain the reinforcement properties and preserve the biodegradability of the cellulose fibers.

The acetate groups suffered cleavage during the deprotection of silylated cellulose acetate with TBAF·3H₂O/THF or TBAF·3H₂O/DMSO. Further investigations revealed regioselective deacetylation (Figure 9) at C2 and C3 carbon positions of the aminoguanidine (AGU). Here, TBA⁺ acts as a general-acid catalyst, whereas F^– induces deacetylation via a ketene intermediate. The formation of the latter was inferred from a kinetic isotope which affects the experiment.

Figure 9.

Deacetylation of cellulose.

2.2. Chemical Synthesis of BPMs

Polymeric materials are chemically synthesized with their structures resembling natural polymeric materials. The polymeric materials containing chains of ester, amide, and peptide bonds are readily biodegradable. The process where many small molecules, called monomers or repeating units, combine to form a covalently bonded chain or network is coined polymerization. The loss of some chemical groups from each monomer may occur during the process. A few synthetic BPMs accompanied by their structures and applications are shown in Table 2.⁹

Table 2. Some Synthetic Biodegradable Polymers.

Synthetic polymerization reactions can be carried out with or without the help of a catalyst. BPMs synthesized in the laboratory are an area of intensive research.

2.2.1. Ring-Opening Polymerization (ROP)

Polymerization where an acyclic monomeric unit is produced from a cyclic monomer is ROP. It is a form of chain-growth polymerization where the terminal end of a polymer chain acts as a reactive center to form a longer polymer chain by opening the ring system of cyclic monomers. There can be three propagating centers: radical, anionic, or cationic. ROP continues to be the most versatile method for the synthesis of major groups of biopolymers to procure product in large quantities.^10a

PLA is synthesized either by the polycondensation of lactic acid or by the chain growth ROP of lactide (Figure 10). Several catalysts and initiators can be used to carry out the ROP of lactide. A commonly used robust catalyst/initiator is Sn(Oct)₂.^10a

Figure 10.

ROP of lactide.

High-molecular-weight PLGA is produced by the ROP of lactide and glycolide, the cyclic diesters of lactic acid and glycolic acid, respectively, under catalyst Sn(Oct)₂ (Figure 11).^10a

Figure 11.

ROP of glycolide and lactide.

PCL is synthesized via ROP of e-caprolactone with Sn(Oct)₂ as a catalyst (Figure 12).^10a

Figure 12.

ROP of e-caprolactone.

ROP of p-dioxanone produces PDS (Figure 13), a relatively weak, rapidly biodegrading polymer which was introduced to the market in the 1980s as a new degradable material to be used for suturing. It generates degradation products that are less acidic than PGA and PLA.^10b

Figure 13.

ROP of p-dioxanone.

Gou et al.^10c synthesized three novel pentablock (PB) copolymers by the bulk ROP method:

• a.poly(glycolic acid)-poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone)-poly(glycolic acid) (PGA-PCL-PEG-PCL-PGA, i.e., PB-A) (Figure 14),
• b.poly(lactic acid)-poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone)-poly(lactic acid) (PLA-PCL-PEG-PCL-PLA, i.e., PB-B),
• c.poly(ethylene glycol)-poly(caprolactone)-poly(lactic acid)-poly(caprolactone)-poly(ethylene glycol) (PEG-PCL-PLA-PCL-PEG, i.e., PB-C)

Figure 14.

Synthesis scheme for the PB-A (PGA-PCL-PEG-PCL-PGA) copolymer.

2.2.2. Free-Radical Polymerization (FRP)

The consecutive addition of building blocks as free radicals, formed by several mechanisms involving separate initiator molecules, to produce polymers is termed FRP. The newly generated initiating free radicals add monomer units to the polymer chain, resulting in its growth. Owing to the nonspecific nature of free-radical chemical interactions, FRP is the most versatile forms of polymerization which allows facile reactions of polymeric free-radical chain ends with other chemicals or substrates.¹¹

2.2.3. Condensation

A condensation reaction is a class of organic addition reaction that typically proceeds in a stepwise fashion, occurring under acidic or basic conditions or in the presence of a catalyst and yielding the addition product in equilibrium. As the name suggests, condensation produces a water molecule. The reaction may also involve the functional groups of the molecule to form a small molecule such as ammonia, ethanol, or acetic acid instead of water. These reactions are a vital part of life as they play an essential role in the generation of peptide bonds between amino acids and the biosynthesis of fatty acids.¹²

Figure 15 shows different techniques such as direct condensation polymerization, azeotropic dehydrative condensation, and polymerization through lactide formation to produce high-molecular-weight PLA. However, currently most of them are produced by lactide ROP.¹²

Figure 15.

Synthesis of PLA from l- and d-lactic acids.

However, the required synthesis conditions were harsh, which resulted in many byproducts, making this method less cost-efficient for the synthesis of BPMs.

2.3. Microbiological Synthesis of BPMs

Microorganisms use organic matter such as glucose and starch as food sources to synthesize a series of complex polymeric materials. These polymeric materials cover a varied sort of silk, polysaccharides, polyesters including poly(hydroxyalkanoates) (PHAs) such as poly(hydroxybutyrate) (PHB) and poly(hydroxy-butyrate-hydroxy-valerate) (PHBV), and PCL. The similarity in their chemical properties makes the separation of these products difficult. Table 3(13) shows the list of the few bacterial polyester PHAs mentioned with the respective radicals as shown in Figure 16.

Table 3. Types of Bacterial Polyester PHAs with Their Specified Radicals^a.

polymer	–R group	applications
poly(hydroxylbutyrate) PHB	–CH3	seam threads for the healing of wounds and blood vessels, creating bioplastics
poly(hydroxylvalerate) PHV	–CH2–CH3	controlled release of drugs, clinical repairs, orthopedic devices
poly(hydroxyhexanoate) PHHex	–(CH2)2–CH3	medical implants, adhesion barriers, stents, vein valves
poly(hydroxyloctanoate) PHO	–(CH2)4–CH3	biomedical grafting, bone marrow scaffolds
poly(hydroxyldecanoate) PHD	–(CH2)6–CH3	drug delivery
poly(hydroxy phenylvalerate) PHPV	–CH2–C6H5	surgical implants, biofuels

^aReproduced with permission from ref (13).

Figure 16.

General structure of PHA.

2.3.1. Poly(hydroxyalkanoates)

PHAs are a class of intracellular biopolymers that are produced by the bacterial fermentation of sugar or lipids to store carbon and energy. Bacterially synthesized PHAs are highly biocompatible and have renewable sources. PHAs are formed mainly from saturated and unsaturated hydroxyalkanoic acids (HAA). The monomer of PHA can be branched or unbranched 3-HAA, and those with substituted side chains are 4- and 5-HAA. PHA can be a homo-, co-, or terpolymer depending on the kind of monomer.¹⁴

2.3.1.1. Poly(hydroxybutyrate)

PHB is a member of the bioderived and biodegradable polyesters that were synthesized from bacteria Bacillus megaterium by Lemoigne in 1925.¹⁵ The generalized chemical structure of PHB is

Takehara¹⁶ biosynthesized poly(3-hydroxybutyrate) (P3HB) through the formation of 3-hydroxybutyryl-CoA and then polymerized it in the presence of enzyme PHB synthase (Figure 17). Microbially produced PHAs have molecular weights of 500 000 to >1 000 000, much higher than that achieved by conventional polycondensation involving hydroxy acid monomers. PHAs typically possess a natural ability to make high-molecular-weight condensation polymers such as proteins, starch, cellulose, and nucleic acids.

Figure 17.

Microbial synthesis of PHB.

Degli et al.¹⁷ studied bone tissue regeneration scaffolds made from PHB, which was obtained by a thermally induced phase separation (TIPS) technique, and the osteoinductivity and osteoconductivity were enhanced through the incorporation of HA to form a block copolymer.

2.3.1.2. Poly(hydroxy-butyrate-hydroxy-valerate)

Ma et al.¹⁸ synthesized high levels of PHBV with a 3-hydroxyvalerate fraction through l-isoleucine producing Corynebacterium glutamicum recombinant strain WM001.

2.4. Enzyme-Mediated Synthesis of BPMs

Enzyme-mediated polymerization is an emerging approach which can compete against conventional chemical synthesis methods and physical modification techniques. Some enzymes show different properties by catalyzing specific polymerizations. The products can be separated easily as these reactions do not produce any byproducts due to the high specificity of enzymes.¹⁹

Via enzyme-mediated synthesis, BPMs such as polyamide, polysaccharide, and polyester can be produced. Furthermore, enzymes can be recycled. Because the catalytic reaction conditions while using enzymes are mild (generally room temperature and atmospheric pressure), the processing cost can be reduced significantly.²⁰

Table 4. Enzymes and Typical Examples of Their Use in Polymer Synthesis and Typical Polymers Synthesized via Enzymatic Polymerization^a.

^aReproduced with permission from ref (19).

Lipase-catalyzed polymerization (LCP) has become an important method for the synthesis of aliphatic polyesters. Itaconic anhydride (IAn) derived from renewable starting materials was used in a ring-opening addition condensation polymerization (ROACP) monomer to undergo LCP and produce good-to-high yields of reactive polyesters possessing vinylidene double bonds (Figure 18).²¹

Figure 18.

ROACP using IAn and diol.

Cheng et al.²² investigated the bulk LCP of diamines and diesters (Figure 19), which resulted in aliphatic polyamides having around a 3000–15 000 g/mol molecular weight. This is the first report showing that high-molecular-weight polyamides can be produced via LCP.

Figure 19.

LCP for aliphatic polyamides.

2.5. Chemoenzymatic Synthesis of BPMs

Enzymatic synthesis adjusts the polymer molecular weight and endows the polymer with both high specificity and stereoselectivity. The chemoenzymatic synthesis method combines conventional polymerization with a highly efficient enzymatic approach. Hence, it can be coined as an attractive strategy for the preparation of high-molecular-weight BPMs.

Researchers have fabricated some optically active polymeric prodrugs as nonsteroidal anti-inflammatory substrates having high molecular weights by using an efficient chemoenzymatic route.

Gutman et al.²³ investigated the lipase-catalyzed ROP of ε-caprolactone (ε-CL) in n-hexane to successfully produce PCL having up to a 4400 g/mol molecular weight (Figure 20).

Figure 20.

Lipase-catalyzed ROP of caprolactone.

3. Conclusions and Future Perspectives

This review summarizes the synthetic preparations for biodegradable polymeric materials. Time was needed for the endangered possibility of the survival of mankind to ensue through nonbiodegradable polymers, and vanishing off-the-shelf natural BPMs have led to increased interest in the synthesis of BPMs. Synthetic BPMs have progressed and touched new heights of synergistic research. Scientists, engineers, biologists, and physicians have tailored their efforts to the properties of synthesized materials, which certainly possess potential. They not only have a dynamically regulated structure and morphology but also show their discrete functions to offer a flexible and robust platform for the design and synthesis of smart BPMs with tailored specifications.

The future prospect of synthetic BPMs seems promising. Current drifts have transposed the focus toward biology in order to understand and then mimic the physiological interactions and signaling. Functional BPMs are a concept which has become crucial in biomedical utilization. The well-defined structure, biodegradability/biostability, mechanical properties, multiple functionalities, stimuli-responsiveness, biocompatibility, and minimum cytotoxicity of these BPMs make them suitable candidates for multifarious applications comprising the development of potential drug/gene delivery systems along with combination therapies, biotemplates, wound healing materials, orthopedic and dental sutures, fixatures and implants, and antimicrobial surfaces; in tissue engineering, cryopreservation, food packaging; and as polymeric biocides and herbicides, biofuels, and superabsorbent polymers.

Owing to the advancement of nanotechnology, particularly when consolidating it with the utilization of BPMs, one can envision this cutting-edge technology as one of the most powerful tools in modern society. BPM-based nanovehicles provide a stable platform for bioimaging and diagnosis as they can potentially survive diverse external stimuli in vitro and in vivo. Due to their tailored self-assembly behavior, BPMs can disperse in aqueous media to retain their nanosized distribution for bioapplications. As the old saying goes, “opportunity always sides with challenges”. Although BPMs provide perfect platforms for biomedical applications, this area still faces several crucial challenges. Many BPMs have been used for in vitro studies, thus one can contemplate a protracted course of action to be explored prior to their application in clinical theragnostic for attaining rehabilitation in the future to avail a revolutionary influence on every aspect of human life.

Glossary

Abbreviations

BPMs

biodegradable polymeric materials

PGA

poly(glycolic acid)

PLA

poly(lactic acid)

PLGA

poly(lactic-co-glycolic acid)

PEG

poly(ethylene glycol)

PBA

poly(butylene succinate)

PCL

polycaprolactone

PEA

poly(ethylene adipate)

PDS

poly(p-dioxanone)

PVL

poly(valerolactone)

CGP

chitosan-grafted-polyacrylamide

(NH₄)₂S₂O₈

ammonium persulfate

Fe₃O₄

iron oxide

EtOH

ethanol

SGPLA

starch-graft-poly(lactic acid)

SGPLGA

starch-graft-poly(lactic acid-co-glycolic acid)

SGPLGC

starch-graft-poly(lactic acid-co-glycolic acid-co-e-caprolactam)

OCS

oxidized cross-linked starch

COS

cross-linked oxidized starch

STMP

sodium trimetaphosphate

TBAF

tetra-n-butylammonium fluoride

DMSO

dimethyl sulfoxide

AGU

aminoguanidine

ROP

ring-opening polymerization

PB

pentablock

FRP

free-radical polymerization

PHB

poly(hydroxybutyrate)

PHBV

poly(hydroxy-butyrate-hydroxy-valerate)

PHHex

poly(hydroxyhexanoate)

PHO

poly(hydroxyloctanoate)

PHD

poly(hydroxyldecanoate)

PHPV

poly(hydroxy phenylvalerate)

HAA

hydroxyalkanoic acids

TIPS

thermally induced phase separation

IAn

itaconic anhydride

ROACP

ring-opening addition condensation polymerization

Biographies

Siddhi S. Panchal received her bachelor’s degree in chemistry (2013–2016) from Gujarat University and her master’s degree in organic chemistry (2016–2018) from the Department of Chemistry, School of Sciences, Gujarat University. Now she is pursuing her doctoral degree in biodegradable polymeric nanomaterials under the guidance of Dr. Dilip V. Vasava in the Department of Chemistry at Gujarat University.

Dilip V. Vasava, B.Ed., Ph.D., assistant professor, Department of Chemistry, School of Sciences, Gujarat University, received his doctoral degree in polymer chemistry from the Veer Narmad South Gujarat University, Surat, Gujarat, India. He has been working on high-performance fluorescent polymers, biodegradable polymers, nanoparticles and nanocomposites, green chemistry, and drug design. He served at St. Xaviers’ College, Ahmedabad, Gujarat, India, for 8 years (2007–2015) and has been at his current affiliation since 2015.

The authors declare no competing financial interest.