Fig. 2. A) Schematic illustration of encapsulated 5-Fu released from ZIF-8 at pH 7.4 and 5.0. B) Scanning electron microscopy (SEM) images of ZIF-8 immersed in different pH solutions at 37 °C for (a) 0 day (as-prepared), (b) 7 days in pH 7.4 buffer, (c) 5 min in pH 5.0 buffer and (d) 15 min in pH 5.0 buffer. C) 5-FU release curve from ZIF-8. D) Synthesis and loading target molecules of ZIF-8 via a one-pot method. E) pH-Responsive release curves of DOX from DOX@ZIF-8particles: (a) typical release system at different pH values and (b) stepped release system. Reprinted, copyright from RSC, 2012 and ACS, 2014.
