Table 1.
In vitro assays on transient receptor potential ankyrin 1 (TRPA1) ion channel.
| TRPA1 | |||
|---|---|---|---|
| Sample | Efficacy (% AITC 100 µM) | Potency EC50 µg/mL | Inhibition IC50 μg/mL (AITC 100 µM) |
| E1 (hexane) | 112.6 ± 4.9 | 9.0 ± 0.9 | 25.7 ± 1.4 |
| E2 (ethylether) | 104.1 ± 7.7 | 15.0 ± 2.9 | 40.9 ± 1.4 |
| E3 (dichloromethane) | 64.8 ± 1.7 | > 20 | > 50 |
| E4 (ethanol) | 19.6 ± 1.9 | > 20 | > 50 |
| E5 (water) 1 | 37.5 ± 1.5 | > 20 | > 50 |
| E6 (methanol) 1 | 99.0 ± 1.7 | 1.3 ± 0.1 | 1.2 ± 0.2 |
| Moringin | 102.6 ± 1.1 | 3.14 ± 0.16 μM | 3.60 ± 0.05 μM |
1 Samples E1-4 from dry leaves; E5 and E6 from frozen leaves. AITC = allylisothiocyanate.