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. 2020 Feb 18;25(4):896. doi: 10.3390/molecules25040896

Figure 3.

Figure 3

Blockade of the Rimonabant-induced adipocyte lipolysis by a CB1R agonist. Primary rat adipocytes were incubated (20 min, 37 °C) in the absence or presence of increasing concentrations of the CB1R agonist, CP55.940, prior to the addition of Rimonabant (final concentration 10 or 1 µM) or dimethyl sulphoxide (DMSO) (Control). After further incubation (3 h, 37 °C), the concentrations of glycerol (■) and fatty acids (●) released into the incubation medium were assayed enzymatically and calculated as fold increases above basal (absence of Rimonabant set as 1). Mean ± SD of incubations in triplicate and measurements in duplicate. * (glycerol),# (fatty acids) p ≤ 0.05 vs. absence of CP55.940; no significant differences with control adipocytes (absence of Rimonabant).