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Flavonoid targets in extrinsic and intrinsic apoptosis pathways. TNF—tumor necrosis factor, tBid—truncated Bid, Bcl-2—B-cell lymphoma protein 2, Bcl-xL—Bcl-2 homologue splice variants, Cyt c—cytochrome c, SMAC—second mitochondrial activator of caspases, IAPs—inhibitor of apoptosis proteins, APAF-1—apoptotic protease activating factor 1. Yellow arrows show the effect of flavonoids (activation or suppression).
