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. 2020 Feb 13;10(2):293. doi: 10.3390/biom10020293

Figure 1.

Figure 1

Indirect evidence for non-canonical biogenesis of miR-4443. Adapted from miRbase (http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016786), with let-7f-5p and miR-21 included for comparison. (A) The predicted stem-loop structure of pre-miR-4443 compared with the structures of pre-let-7f-5p and pre-miR-21. Mature microRNA sequences are shown in gray. (B) The deep sequencing evidence for mature miR-4443, compared with let-7f-5p and miR-21. Note the short (17 nt) mature sequence, short terminal loop, and lack of evidence for passenger strand for miR-4443.