Figure 4.
The effect of machilin D on the tumor growth in a xenograft model. MDA-MB-231 cells (2 × 106 cells/mouse) were inoculated into the mammary fat pad of female nude mice and treated with machilin D or DMSO (n = 6). The drug concentration was 10 mg/kg. (A) The body weights of the machilin D-treated group were comparable with those of the control group. (B) The tumor volume was calculated as (width2 × length)/2 at the indicated time points. (C) The mouse images of the control and machilin D-treated groups were captured with a camera at day 30. (D) Tumor weights of the control and machilin D-treated mice were assayed after sacrifice at day 30. The data are presented as the mean ± SD of three independent experiments. ** p < 0.05; *** p < 0.01 versus the DMSO-treated control group indicated significant differences.