Table 2.
Long noncoding RNAs regulating cardiac regeneration through control of cardiomyogenesis.
| ncRNA | Model | Therapy | Observed Effect | Reference |
|---|---|---|---|---|
| CARMEN | P19CL-6 | shRNA-mediated INH | CM differentiation ↓, CM proliferation ↓ | [8] |
| ANRIL | HEK293 | Stable cell line | Cell adhesion ↑, growth ↑, metabolic activity ↑, apoptosis ↓ | [107] |
| Braveheart | mESC | shRNA-mediated INH | CM differentiation ↓ | [131] |
| Braveheart | nRCM | shRNA-mediated INH | CM size ↓, differentiation ↓ | [131] |
| Fendrr | Embryonic mouse | Transgenic KO | CM proliferation ↓, ventricular defects | [9,112] |
| H19 | P-ESC | shRNA-mediated INH | CM differentiation ↓ | [114] |
ShRNA, Short hairpin; CM, Cardiomyocyte; INH, inhibition; KO, Knock-out; mESC, Mouse embryonic stem cell P-ESC, Parthenogenetic embryonic stem cell; nRCM, Neonatal Rat Cardiac Myocyte.