. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Traffic. 2019 Sep 12;20(11):829–840. doi: 10.1111/tra.12691

Table 1.

Key constituents of the mRNA export machinery

Yeast	Human	Function
Mex67•Mtr2	NXF1•NXT1 (TAP•p15)	Principal export receptor for bulk mRNA export

In the nucleus
Sub2	UAP56	DEAD-box ATPase that remodels nuclear mRNP, component of the TREX complex
Yra1	ALY (REF, THOC4)	Adaptor for the export receptor, component of the TREX complex
THO	THO	A multi-subunit complex, component of the TREX complex
Nab2	ZC3H14	Poly(A) RNA binding protein
TREX-2	TREX-2	A multi-subunit complex that targets actively transcribed genes to the NPC

At the NPC cytoplasmic face
Dbp5	DDX19	DEAD-box ATPase that remodels mRNP at the cytoplasmic side of the NPC
Gle1	GLE1	Activator of Dbp5/DDX19, requires IP₆ for mRNA export
Nup42	NUP42 (hCG1)	FG-Nucleoporin to which Gle1/GLE1 binds
Nup159	NUP214 (CAN)	FG-Nucleoporin to which Dbp5/DDX19 binds
Nup116	NUP98	FG-Nucleoporin, binds to the export receptor
Gle2	RAE1	mRNA export factor, binds to Nup116/NUP98