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Time-dependent concentration profiles of 1,1′-Dioctadecyl-3,3,3′,3′-Tetramethylindotricarbocyanine Iodide (DiR)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoaprticles following intranasal administration. Concentration of DiR in (A) blood plasma, (B) whole brain, and (C) whole spinal cord after intranasal administration. Graphs show the mean ± SEM (n = 5–6).
