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Sequestration of siderophores as an antimicrobial strategy. B. anthracis secretes two siderophores, BB and PB. Scn, which is produced by neutrophils and other human cell types, binds BB and its ferric complex, thus depleting it as a microbial source of iron. Additional administration of Pcn, an engineered variant of Scn that binds ferric PB with high affinity, blocks the pathogen's second route to iron and results in effective growth inhibition.
