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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Biomaterials. 2020 Feb 21;241:119906. doi: 10.1016/j.biomaterials.2020.119906

Fig. 1. Mouse otoferlin FerA domain increased AAV transduction in vivo via systemic administration.

Fig. 1.

5×1010 vg of AAV9/luc alone or the complex of AAV9/luc incubated with mOto-FerA at multiple molecule ratios (1:0, 1:200, 1:2000, 1:20,000, and 1:200,000 is equal to 0 μg, 0.005 μg, 0.05 μg, 0.5 μg, and 5 μg, respectively) were administered via intravenous injection. Luminescence imaging was performed (A) and the photon signal was measured and calculated (B) on day 1 and day 3. The data of each group represent the average and SD from five mice. *** p < 0.001, ** p < 0.01, and *p < 0.05 compared to control mice with AAV9/luc treatment only.