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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Biomaterials. 2020 Feb 21;241:119906. doi: 10.1016/j.biomaterials.2020.119906

Fig. 3. Mouse otoferlin FerA enhanced the transduction of AAV8 and AAV6 vectors in vivo by systemic injection.

Fig. 3.

1×1010 vg of AAV8/luc or AAV6/luc with or without pre-incubation of mOto-FerA were injected into the 5-6-week-old female C57BL/6 mice via the retro-orbital injection. Imaging was carried out (A and D) and photon signal was calculated (B and E) at day 3, 7, and 14 after vector administration. The viral gene copy numbers (C and F) in liver were determined by qPCR. The data of each group represent the average and SD from five mice. **p <0.01 and *p < 0.05 compared to control mice with AAV/luc treatment only.