Skip to main content
. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Biomaterials. 2019 Jun 21;217:119292. doi: 10.1016/j.biomaterials.2019.119292

Figure 7. Example particle utilizing boronic ester bonds as a ROS-responsive bond cleavage site.

Figure 7

(a) Schematic of the multilayered stroke-targeting nanoparticles made from an outer shell consisting of a red blood cell membrane modified with a stroke homing peptide (CLEVSRKNC), an inner shell consisting of the ROS-responsive dextran modified with boronic esters encapsulating a neuroprotective agent (NR2B9C). (b) Outline of the activity of the particle to use the stroke homing peptide, which targets glutamate receptors, to guide the particle to ischemic neurons. Following internalization, the ROS-cleavable boronic ester-modified dextran cell disassembles and releases the NR2B9C which interactions with N-methyl-d-aspartate receptors (NMDAR) to prevent toxic nitric oxide production within the cell. Reprinted (adapted) with permission from [137]. Copyright 2018 American Chemical Society.