Table 1. Summary of the experimental design, attack rates (AR), survival times (ST) and global immunohistochemical results on the central nervous system (CNS), peripheral nervous system (PNS), gut-associated lymphoid tissues (GALT) and non-GALT (nGALT).
| Strain | Host | Route | Recipients | AR | ST | CNS | PNS | GALT | nGALT |
|---|---|---|---|---|---|---|---|---|---|
| ME7 | Suff AA | Oral | 3 | 2/3R | 763, 1209 | 8.4 | 4.6 | 0.4 | 1.8 |
| Combined | 3 | 3/3R | 365 ± 256 | 7.6 | 3.2 | 12 | 3.8 | ||
| Chev VV | Oral | 5 | 4/4 | 1146 ± 193 | 11.6 | 6.6 | 9.1 | 35.7 | |
| Combined | 3 | 3/3 | 659 ± 100 | 9.1 | 3.1 | 4.7 | 19.2 | ||
| Chev AA | Oral | 5ID1 | 4/4 | 1388 ± 12 | 11 | 5 | 2.5 | 10.2 | |
| Combined | 3 | 3/3 | 624 ± 60 | 5.7 | 0.9 | 0 | 2.2 | ||
| 79A | Suff AA | Oral | 3 | 0/3R, * | - | - | - | - | - |
| Combined | 3 | 3/3R | 653 ± 335 | 7.7 | 1 | 0 | 0.4 | ||
| Chev VV | Oral | 3 | 1/3 | 481 | 6.9 | 3.1 | 1 | 5.4 | |
| Combined | 3ID1 | 2/2 | 671, 743 | 8.8 | 0.7 | 4.1 | 12.4 | ||
| Chev AA | Oral | 3 | 1/3* | 2450 | 7.5 | 0.5 | 0 | 1.7 | |
| Combined | 3ID1 | 2/2 | 647, 1043 | 5.5 | 0.2 | 0 | 1.7 | ||
| 22A | Suff AA | Oral | 3 | 2/3* | 2274* | 0.5 | 0 | 0 | 0 |
| Combined | 3 | 3/3 | 592 ± 575 | 7.3 | 1.3 | 3.7 | 16.4 | ||
| Chev VV | Oral | 3ID2 | 1/2 | 1865 | 12.3 | 2.1 | 1.3 | 14.4 | |
| Combined | 3ID1 | 2/2 | 259, 479 | 8.9 | 1.5 | 3.1 | 18.3 | ||
| Chev AA | Oral | 3 | 3/3 | 2107 ± 296 | 6.3 | 1 | 4 | 13.5 | |
| Combined | 3 | 3/3 | 687 ± 270 | 7.2 | 0.4 | 4.9 | 16.9 | ||
| 87V | Suff AA | Oral | 3 | 0/3 | - | - | - | - | - |
| Combined | 3 | 3/3R | 991 ± 607 | 9.1 | 0 | 0 | 0 | ||
| Chev VV | Oral | 3 | 0/3 | - | - | - | - | - | |
| Combined | 3 | 3/3 | 687 ± 156 | 14.4 | 0 | 0 | 0 | ||
| Chev AA | Oral | 3 | 0.3 | - | - | - | - | - | |
| Combined | 3 | 3/3 | 509 ± 85 | 10.1 | 0 | 0 | 0 | ||
Standard deviations are given for the ST (in days) to highlight individual variation. Scores for the different compartments indicate the sum of the averaged magnitude of PrPd in each individual tissue or area contained in each compartment. The combined route (in italic) includes the oral, sub-cutaneous and intracerebral routes. All groups, except for the oral ME7 Cheviot sheep, which had a total of five VRQ and five ARQ sheep, initially contained a total of three sheep. However, some sheep died of intercurrent deaths before the first positive animal of that group did and are excluded from the table. The superscript (ID) followed by a number in the column of recipients indicates the number of sheep that died with intercurrent deaths. The superscript R indicates that one animal in that group was polymorphic at codon M112T (R). An asterix (*) designates culled at the end of the experiment. Survival times (in days), which are defined as the interval of days between the inoculation date and the post-mortem, are only given for sheep that were demonstrably infected, and are given as individual values rather than as an average if groups are smaller than three sheep.