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. 2020 Mar 23;6(1):00272-2019-ERR. doi: 10.1183/23120541.50272-2019

“Understanding the mechanism of bronchial thermoplasty using airway volume assessed by computed tomography” David Langton, Peter B. Noble, Frank Thien and Graham M. Donovan. ERJ Open Res 2019; 5: 00272-2019.

PMCID: PMC7086069  PMID: 32211436

This article was originally published with an error in the caption of figure 1. The corrected caption is shown below, and the article has been corrected and republished online.

FIGURE 1 Comparison of volume of bronchial thermoplasty (BT)-treated airways in a, c, d and f) each patient as assessed by computed tomography (CT) (18 patients) and model predictions (20 simulations). CT measurements at a, d and g) functional residual capacity (FRC) and c, f and h) total lung capacity (TLC) are compared with b and e) model predictions. Model predictions are for fatal asthma at a low level of airway smooth muscle activation [5]. The response threshold is defined as an increase in airway volume that exceeds half of the interquartile range of the intervisit variability, as assessed on the untreated right side (∼8.5% at FRC and ∼17% at TLC). p-values reflect paired t-tests. The untreated right lung was not modelled. Subject characteristics were as follows. Males: seven out of 18 patients; mean±SD age 57.6±14.2  years; BMI: 32.1±7.2 kg·m−2; cigarettes: 10 never-smokers, eight ever-smokers; Asthma Control Questionnaire (ACQ) score (baseline): 3.5±0.9; oral steroids: 15/18 mg·day−1, mean 14.3±15.8 mg·day−1; forced expiratory volume in 1 s: 44.9±13.7% pred; ACQ score after one lung treated: 2.4±1.2. The protocol was prospectively reviewed and approved by the Peninsula Health Human Research Ethics Committee. LLL: left lower lobe; LUL: left upper lobe; RUL: right upper lobe; RLL: right lower lobe; RML: right middle lobe.


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