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. 2020 Mar 4;10(9):4201–4216. doi: 10.7150/thno.35589

Figure 1.

Figure 1

Up-regulation of ERRα is associated with CRPC. (A) ERRα immunohistochemistry. Representative micrographs of ERRα-immunostained tissue microarray spots of BPH and malignant lesions. A significant increase in malignant cells with positive and intense nuclear ERRα immunosignals was detected in adenocarcinoma lesions with higher Gleason scores. Magnification, ×40; scale bars, 250 μm. Insets show the enclosed areas at higher magnification. Magnification, ×200; scale bars, 50 μm. (B) ERRα immunoreactivity score analysis (ERRα‐IRS) performed on BPH and neoplastic prostatic tissues. Adenocarcinomas with higher Gleason scores (GS ≥ 7) showed significantly higher ERRα expression than BPH tissues. (C) Kaplan-Meier analysis of Grasso et al. 2012 study cohort (GSE35988) of CRPC revealed that higher ERRα mRNA expression was positively correlated with shortened overall survival of prostate cancer patients relapsed from hormone therapy.