Table 2.

Phenotypes of REV-ERBα ablation and the underlying mechanisms

Tissues	Phenotypes	Mechanisms	Refs
Liver	Fulminant hepatitis, IL-1β and IL-18 secretion	NLRP3 inflammasome, Transcription of Nlrp3 and IL-1β	27
Liver	Diabetes	Transcription of PCK and G6Pase	6, 57-61
Liver	Hyperlipidemia	Transcription of ApoC-III and Elovl3	6,69,70,72
Liver	Hypercholesterolemia	Expression of HMGCR and CYP7A1	71,74-76
Liver	Hyperhomocysteinemia	Transcription of Bhmt, Cbs, Cth and C/EBPα	80
Lung	Pulmonary inflammation	Expression of chemokines and inflammatory cytokines	40
Lung	Pulmonary fibrosis	TBPL1-integrinβ1 pathway	56
Colon	Ulcerative colitis	NF-κB signaling pathway, NLRP3 inflammasome, Transcription of Nlrp3	25
Heart	Ischaemia-reperfusion injury, Immunocyte recruitment	NLRP3 inflammasome	36
Heart	Perioperative myocardial injury	Expression of CDKN1a/p21.	30
Bone	Osteoporosis, Osteoclastogenesis	Expression of FABP4	84
Bone	Osteogenesis	Expression of bone sialoprotein	85
Pancreas	Glucose-induced insulin secretion in β-cells, Glucagon secretion in α-cells	Exocytotic process, AMPK/Nampt/Sirt1 pathway	62-64