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. 2005 Jun 28;150(11):2299–2311. doi: 10.1007/s00705-005-0573-2

Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia

P C Y Woo 1,2,3, S K P Lau 1,2,3, Y Huang 1, H-W Tsoi 1, K-H Chan 1, K-Y Yuen 1,2,3
PMCID: PMC7086700  PMID: 15986174

Summary.

Phylogenetic trees constructed using predicted amino acid sequences of putative proteins of coronavirus HKU1 (CoV-HKU1) revealed that CoV-HKU1 formed a distinct branch among group 2 coronaviruses. Of the 14 trees from p65 to nsp10, nine showed that CoV-HKU1 was clustered with murine hepatitis virus. From nsp11, the topologies of the trees changed dramatically. For the eight trees from nsp11 to N, seven showed that the CoV-HKU1 branch was the first branch. The codon usage patterns of CoV-HKU1 differed significantly from those in other group 2 coronaviruses. Split decomposition analysis revealed that recombination events had occurred between CoV-HKU1 and other coronaviruses.

Keywords: Hepatitis, Codon, Infectious Disease, Pneumonia, Amino Acid Sequence

Footnotes

These authors contributed equally to the manuscript.

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