Summary
After intranasal inoculation of suckling rats mouse hepatitis virus multiplied mostly in the nasal epithelium; though there were no symptoms, antibodies were produced. Antibodies were also demonstrated in adult rats. These findings suggest that the rat may be a natural host for the virus.
Keywords: Hepatitis, Infectious Disease, Hepatitis Virus, Natural Host, Asymptomatic Infection
Footnotes
With 2 Figures
References
- 1.Bailey O. T., Pappenheimer A. M., Cheever F. S., Daniels J. B. A murine virus (JHM) causing disseminated encephalitis with extensive destruction of myelin. II. Pathology. J. exp. Med. 1949;90:195–212. doi: 10.1084/jem.90.3.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Bhatt P. N., Jacoby R. O. Experimental infection of adult axenic rats with Parker's coronavirus. Arch. Virol. 1977;54:345–352. doi: 10.1007/BF01314779. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Bhatt P. N., Jacoby R. O., Jonas A. M. Respiratory infection in mice with sialodacryoadenitis virus, a coronavirus of rats. Infect. Immun. 1977;18:823–827. doi: 10.1128/iai.18.3.823-827.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Broderson J. L., Murphy F. A., Hierholzer J. C. Lethal enteritis in infant mice caused by mouse hepatitis virus. Lab. Anim. Sci. 1976;25:824. [PubMed] [Google Scholar]
- 5.Cheever F. D., Daniels J. B., Pappenheimer A. M., Bailey O. T. A murine virus (JHM) causing disseminated encephalitis with extensive destruction of myelin. I. Isolation and biological properties of the virus. J. exp. Med. 1949;90:181–194. [Google Scholar]
- 6.Fujiwara K. Problems in checking inapparent infections in laboratory mouse colonies. An attempt at serological checking by anamnestic response. In: Schneider H. A., editor. Defining of the laboratory animals. Washington D.C.: National Academy of Science; 1971. pp. 71–92. [Google Scholar]
- 7.Gledhill A. W., Dick G. W. A., Niven J. S. F. Mouse hepatitis virus and its pathogenic action. J. Path. Bact. 1955;62:299–309. doi: 10.1002/path.1700690138. [DOI] [PubMed] [Google Scholar]
- 8.Hartley J. W., Rowe W. P., Bloom H. H., Turner H. C. Antibodies to mouse hepatitis virus in human sera. Proc. Soc. exp. Biol. Med. 1964;115:414–418. doi: 10.3181/00379727-115-28928. [DOI] [PubMed] [Google Scholar]
- 9.Hirano N., Takenaka T., Fujiwara K. Pathogenicity of mouse hepatitis virus for mice depending upon host age and route of infection. Japan. J. exp. Med. 1975;45:287–294. [PubMed] [Google Scholar]
- 10.Hirano N., Tamura T., Taguchi F., Ueda K., Fujiwara K. Isolation of low-virulent mouse hepatitis virus from nude mice with wasting syndrome and hepatitis. Japan. J. exp. Med. 1975;45:429–432. [PubMed] [Google Scholar]
- 11.Jacoby R. O., Bhatt P. N., Jonas A. M. Pathogenesis of sialodacryoadenitis in gnotobiotic rats. Vet. Pathol. 1975;12:196–209. doi: 10.1177/030098587501200305. [DOI] [PubMed] [Google Scholar]
- 12.Parker J. C., Cross S. S., Rowe W. P. Rat coronavirus (RCV): a prevalent, naturally occurring pneumotic virus of rats. Arch. ges. Virusforsch. 1970;31:293–302. doi: 10.1007/BF01253764. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Piazza M. Experimental viral hepatitis. Springfield, Illinois, U.S.A.: Charles C Thomas; 1969. [Google Scholar]
- 14.Rowe W. P., Hartley J. W., Capps W. I. Mouse hepatitis virus infection as a highly contagious, prevalent, enteric infection of mice. Proc. Soc. exp. Biol. Med. 1963;112:161–165. doi: 10.3181/00379727-112-27980. [DOI] [PubMed] [Google Scholar]
- 15.Taguchi F., Hirano N., Kiuchi Y., Fujiwara K. Difference in response to mouse hepatitis virus among susceptible mouse strains. Japan. J. Microbiol. 1976;20:293–302. doi: 10.1111/j.1348-0421.1976.tb00991.x. [DOI] [PubMed] [Google Scholar]
- 16.Taguchi F., Aiuchi M., Fujiwara K. Age-dependent response of mice to a mouse hepatitis virus, MHV-S. Japan. J. exp. Med. 1977;47:109–115. [PubMed] [Google Scholar]