Summary
Gut contents of nude and normal mice were examined by electron microscopy in association with an outbreak of diarrhea in a colony of nude mice. Virus-like particles with a morphology consistent with previous descriptions of astroviruses of other species were demonstrated in a high percentage of the animals.
Keywords: Electron Microscopy, Infectious Disease, Diarrhea, Nude Mouse, Normal Mouse
Footnotes
With 1 Figure
References
- 1.Broderson J. R., Murphy F. A., Hierholzer J. C. Lethal enteritis in infant mice caused by mouse hepatitis virus. Lab. Anim. Sci. 1976;26:824. [PubMed] [Google Scholar]
- 2.Carthew P. Lethal intestinal virus of infant mice is mouse hepatitis virus. Vet. Rec. 1977;101:465. [PubMed] [Google Scholar]
- 3.Cheever F. S., Mueller J. H. Epidemic diarrheal disease of suckling mice. I. Manifestations, epidemiology and attempts to transmit the disease. J. Exp. Med. 1947;85:405–416. doi: 10.1084/jem.85.4.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Gray E. W., Angus K. W., Snodgrass D. R. Ultrastructure of the small intestine in astrovirus-infected lambs. J. gen. Virol. 1980;49:71–82. doi: 10.1099/0022-1317-49-1-71. [DOI] [PubMed] [Google Scholar]
- 5.Herring A. J., Gray E. W., Snodgrass D. R. Purification and characterization of ovine astrovirus. J. gen. Virol. 1981;53:47–55. doi: 10.1099/0022-1317-53-1-47. [DOI] [PubMed] [Google Scholar]
- 6.Hoshino Y., Zimmer J. F., Moise N. S., Scott F. W. Detection of astroviruses in feces of a cat with diarrhea. Arch. Virol. 1981;70:373–376. doi: 10.1007/BF01320252. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Kjeldsberg E., Mortensson-Egnund K. Comparison of solid-phase immune electron microscopy, direct electron microscopy and enzyme-linked immunosorbent assay for detection of rotavirus in faecal samples. J. Virol. Methods. 1982;4:45–53. doi: 10.1016/0166-0934(82)90053-2. [DOI] [PubMed] [Google Scholar]
- 8.Kraft L. M. An apparently new lethal virus disease of infant mice. Science. 1962;137:282–283. doi: 10.1126/science.137.3526.282. [DOI] [PubMed] [Google Scholar]
- 9.Kraft L. M. Epizootic Diarrhea of Infant Mice and Lethal Intestinal Virus Infection of Infant Mice. Natl. Cancer. Inst. Monogr. 1966;20:55–61. [PubMed] [Google Scholar]
- 10.Madeley C. R., Cosgrove B. P. Viruses in infantile gastroenteritis. Lancet. 1975;2:124. doi: 10.1016/s0140-6736(75)90020-3. [DOI] [PubMed] [Google Scholar]
- 11.McNulty M. S., Curran W. L., McFerran J. B. Detection of astroviruses in turkey faeces by direct electron microcopy. Vet. Rec. 1980;106:561. doi: 10.1136/vr.106.26.561. [DOI] [PubMed] [Google Scholar]
- 12.Much D. H., Zajac I. Purification and characterization of epizootic diarrhea of infant mice virus. Infect. Immun. 1972;6:1019–1024. doi: 10.1128/iai.6.6.1019-1024.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Snodgrass D. R., Gray E. W. Detection and transmission of 30 nm virus particles (astroviruses) in faeces of lambs with diarrhea. Arch. Virol. 1977;55:287–291. doi: 10.1007/BF01315050. [DOI] [PubMed] [Google Scholar]
- 14.Sugiyama K., Amano Y. Morphological and biological properties of a new coronavirus associated with diarrhea in infant mice. Arch. Virol. 1981;67:241–251. doi: 10.1007/BF01318134. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Tyrrell D. A. J., Kapikian A. Z. Virus infections of the gastrointestinal tract. New York: Marcel Dekker; 1982. [Google Scholar]
- 16.Woode G. N., Bridger J. C. Isolation of small viruses resembling astroviruses and caliciviruses from acute enteritis of calves. J. Med. Microbiol. 1978;11:441–452. doi: 10.1099/00222615-11-4-441. [DOI] [PubMed] [Google Scholar]