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. 1993;130(1):171–178. doi: 10.1007/BF01319005

Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates

J Norimine 1, T Miyazawa 1, Y Kawaguchi 1, K Tomonaga 1, Y -S Shin 1, T Toyosaki 1, M Kohmoto 1, M Niikura 1, Y Tohya 1, T Mikami 1
PMCID: PMC7087261  PMID: 8389115

Summary

To investigate whether the feline CD 4 (fCD 4) molecules are involved in infections of highly lymphotropic feline immunodeficiency virus (FIV) isolates, we expressed fCD 4 stably on Crandell feline kidney cells andFelis catus whole foetus 4 cells by transfection of a cDNA encoding the fCD 4 glycoprotein, and then infected them with TM 1 and TM 2 strains of FIV, which are unable to infect these cells productively. In spite of fCD 4 being expressed on these cells, no virus production was observed. This result indicates that fCD 4 expression alone cannot induce a productive infection of the FIV TM 1 and TM 2 strains.

Keywords: Infectious Disease, Kidney Cell, Virus Isolate, Virus Production, Feline Immunodeficiency Virus

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