Skip to main content
PMC home page
Springer Nature - PMC COVID-19 Collection logoLink to Springer Nature - PMC COVID-19 Collection
. 1979;60(3):249–255. doi: 10.1007/BF01317496

Studies on avian infectious bronchitis virus (IBV)

III. Interferon induction by and sensitivity to interferon of IBV

K Otsuki 1, J Maeda 1, H Yamamoto 1, M Tsubokura 1
PMCID: PMC7087316  PMID: 228636

Summary

The induction of interferon by avian infectious bronchitis virus (IBV) and the sensitivity of IBV to interferon were studied. The results of experiments with ten IBV strains are summarized as follows. 1. All the IBV strains tested induced interferon in chick embryo (CE) cells, chicken kidney (CK) cells and embryonated eggs. The Iowa-609 strain induced about 1000 units of interferon in CE cells while the Beaudette-42 strain induced about 200 units of interferon in embryonated eggs; the interferon titers induced by other strains usually ranged from 5 to 60 units. No IBV strain induced interferon in HeLa or BHK-21 cells. 2. IBV particles inactivated by ultraviolet irradiation or by heating lost their ability to induce interferon. 3. The properties of the interferon produced in the present study are similar to those of other interferons produced in chicken cells. 4. HeLa or BHK-21 cells did not acquire resistance to virus infection, after incubation with interferon produced in CE cells. On the other hand, CK cells acquired the same degree of resistance to virus infection as CE cells after incubation with interferon produced in CE cells. 5. All the IBV strains tested were sensitive to interferon in CK cells. The sensitivities of Massachusetts-41 and Holte strains to interferon were similar to that of vesicular stomatitis virus.

Keywords: Infectious Disease, Virus Infection, Interferon, Bronchitis, Ultraviolet Irradiation

Footnotes

With 2 Figures

References

  • 1.Beard C. W. Infectious bronchitis virus interference with Newcastle disease virus in monolayers of chicken kidney cells. Avian Dis. 1967;11:399–406. [PubMed] [Google Scholar]
  • 2.de Mayer E., Enders J. F. Growth characteristics, interferon production and plaque formation with different lines of Edmonston measles virus. Arch. ges. Virusforsch. 1965;16:151–160. doi: 10.1007/BF01253804. [DOI] [PubMed] [Google Scholar]
  • 3.Finter N. B. Interferon production and sensitivity of Semliki Forest virus variants. J. Hyg. 1964;62:337–349. doi: 10.1017/s0022172400040055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Gomez L., Raggi L. G. Local immunity to avian infectious bronchitis in tracheal organ culture. Avian Dis. 1974;18:346–368. [PubMed] [Google Scholar]
  • 5.Groupé V. Demonstration of an interference phenomenon associated with infectious bronchitis virus (IBV) of chickens. J. Bacteriol. 1949;58:23–32. [PMC free article] [PubMed] [Google Scholar]
  • 6.Groupé V., Pugh L. H. Interference between influenza virus and infectious bronchitis virus of chickens. J. Bacteriol. 1952;63:295–296. doi: 10.1128/jb.63.2.295-296.1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Hanson L. E. Separation of Newcastle disease and infectious bronchitis viruses in mixed infections. Poult. Sci. 1954;33:223–230. [Google Scholar]
  • 8.Ho M. Interferons. New Engl. J. Med. 1962;266:1258–1264. doi: 10.1056/NEJM196206212662506. [DOI] [PubMed] [Google Scholar]
  • 9.Lombardi D. Studio nello embrione di pollo fenomeno di interferenza frata tipo Massachusetts e Connecticut del virus della bronchite infettiva. Riv. Inst. sieroter. ital. 1965;40:238–242. [PubMed] [Google Scholar]
  • 10.Lomniczi B. Studies on interferon production and interferon sensitivity of different strains of Newcastle disease virus. J. gen. Virol. 1973;21:305–313. doi: 10.1099/0022-1317-21-2-305. [DOI] [PubMed] [Google Scholar]
  • 11.Lomniczi B. Interferon induction by different strains of infectious bronchitis virus. Acta vet. hung. 1974;24:199–204. [PubMed] [Google Scholar]
  • 12.Otsuki, K., Yamamoto, H., Tsubokura, M.: Studies on avian infectious bronchitis virus (IBV). I. Resistance of IBV to chemical and physical treatments. Arch. Virol. (in press). [DOI] [PMC free article] [PubMed]
  • 13.Otsuki, K., Noro, K., Yamamoto, H., Tsubokura, M.: Studies on avian infectious bronchitis virus (IBV). II. Propagation of IBV in several cultured cells. Arch. Virol. (in press). [DOI] [PubMed]
  • 14.Raggi L. G., Lee G. G., Schrab-Haghighat V. Infectious bronchitis virus interference with growth of Newcastle disease virus. I. Study of interference in chicken embryos. Avian Dis. 1963;7:106–122. [PubMed] [Google Scholar]
  • 15.Rokutanda H. K. Relationship between viremia and interferon production of Japanese encephalitis virus. J. Immunol. 1969;102:662–670. [PubMed] [Google Scholar]
  • 16.Ruiz-Gomez J., Isaacs A. Interferon production by different viruses. Virology. 1963;19:8–12. doi: 10.1016/0042-6822(63)90018-7. [DOI] [PubMed] [Google Scholar]
  • 17.Stewart W. E., II, Scott W. D., Sulkin S. E. Relative sensitivities of viruses to different species of interferon. J. Virol. 1969;4:147–153. doi: 10.1128/jvi.4.2.147-153.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Yurov K. P. Interferon formation in chick embryos infected with one or two viruses. Acta virol. 1967;11:494–499. [PubMed] [Google Scholar]

Articles from Archives of Virology are provided here courtesy of Nature Publishing Group

RESOURCES