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. 1978;58(1):45–53. doi: 10.1007/BF01315534

Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species

N C Pedersen 1, J Ward 2, W L Mengeling 3
PMCID: PMC7087319  PMID: 81044

Summary

Utilizing the direct and indirect fluorescent antibody procedure, the antigenic relationship of the feline infectious peritonitis virus (FIPV) to 7 other human and animal coronaviruses was studied. FIPV was found to be closely related to transmissible gastroenteritis virus (TGEV) of swine. Transmissible gastroenteritis virus and FIPV were in turn antigenically related to human coronavirus 229E (HCV-229E) and canine coronavirus (CCV). An interesting finding in the study was that the 8 coronaviruses selected for this study fell into one of two antigenically distinct groups. Viruses in each group were antigenically related to each other to varying degrees, but were antigenically unrelated to coronaviruses of the second group. The first antigenically related group was comprised of mouse hepatitis virus, type 3 (MHV-3), hemeagglutinating encephalomyelitis virus 67N (HEV-67N) of swine, calf diarrhea coronavirus (CDCV), and human coronavirus OC43 (HCV-OC43). The second antigenically related group was comprised of FIPV, TGEV, HCV-229E and CCV.

Keywords: Hepatitis, Diarrhea, Peritonitis, Hepatitis Virus, Gastroenteritis

Footnotes

With 2 Figures

This research was supported by grants from the Winn Foundation of the Cat Fanciers of America and the S.O.C.K. Organization, Lafayette, California.

References

  • 1.Binn L. N., Lazar E. C., Keenan K. P., Huxsoll D. L., Marchwicki R. H., Strano A. J. Recovery and characterization of a coronavirus from military dogs with diarrhea. Proc. U. S. Animal Health Assoc. 1974;78:359–366. [PubMed] [Google Scholar]
  • 2.Bohac J., Derbyshire J. B. The detection of transmissible gastroenteritis viral antibodies by immunodiffusion. Canad. J. comp. Med. 1976;40:161–165. [PMC free article] [PubMed] [Google Scholar]
  • 3.Bradburne A. F. Antigenic relationships amongst coronaviruses. Arch. ges. Virusforsch. 1970;31:352–364. doi: 10.1007/BF01253769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Dick G. W. A., Niven J. S. F., Gledhill A. W. A virus related to that causing hepatitis in mice (MHV) Brit. J. exp. Pathol. 1956;37:90–98. [PMC free article] [PubMed] [Google Scholar]
  • 5.Estola, T.: Studies on the infectious bronchitis virus of chickens isolated in Finland. Acta. Vet. Scand. Suppl.18 (1966).
  • 6.Greig A. S., Mitchell D., Corner A. H., Bannister G. L., Meands E. B., Julian R. J. A hemagglutinating virus producing encephalomyelitis in baby pigs. Canad. J. comp. Med. vet. Sci. 1962;26:49–56. [PMC free article] [PubMed] [Google Scholar]
  • 7.Hambre D., Procknow J. J. A new virus isolated from the human respiratory tract. Proc. Soc. exp. Biol. Med. 1966;121:190–193. doi: 10.3181/00379727-121-30734. [DOI] [PubMed] [Google Scholar]
  • 8.Horzinek M. C., Osterhaus A. D. M. E., Ellens D. J. Feline infectious peritonitis virus. Zbl. Vet. Med. B. 1977;24:398–405. doi: 10.1111/j.1439-0450.1977.tb01013.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Kaye H. S., Yarbrough W. B., Reed C. J., Harrison A. K. Antigenic relationship between human corona virus strain OC 43 and hemagglutinating encephalomyelitis virus strain 67N of swine: antibody responses in human and animal sera. J. inf. Dis. 1977;135:201–209. doi: 10.1093/infdis/135.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.McIntosh K., Dees J. H., Becker W. B., Kapikian A. Z., Chanock R. M. Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease. Proc. Natl. Acad. Sci. 1967;57:933–940. doi: 10.1073/pnas.57.4.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.McIntosh K., Kapikian A. Z., Hardison K. A., Hartley J. W., Chanock R. M. Antigenic relationship among the coronaviruses of man and between human and animal coronaviruses. J. Immunol. 1969;102:1109–1118. [PubMed] [Google Scholar]
  • 12.Monto A. S., Rhodes L. M. Detection of coronavirus infection of man by immunofluorescence. Proc. Soc. exp. Biol. Med. 1977;155:143–148. doi: 10.3181/00379727-155-39761. [DOI] [PubMed] [Google Scholar]
  • 13.Osterhaus A. D. M. E., Horzinek M. C., Reynolds D. J. Seroepidemiology of feline infectious peritonitis virus infections using transmissible gastroenteritis virus as antigen. Zbl. Vet. Med. B. 1977;24:835–841. doi: 10.1111/j.1439-0450.1977.tb00976.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Parker J. C., Cross S. S., Rowe W. P. Rat corona virus (RCV): a prevalent, naturally occurring pneumotropic virus of rats. Arch. ges. Virusforsch. 1970;31:293–302. doi: 10.1007/BF01253764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Pedersen N. C. Serologic studies of naturally occurring feline infectious peritonitis. Amer. J. vet. Res. 1976;37:1449–1453. [PubMed] [Google Scholar]
  • 16.Pedersen N. C. Morphologic and physical characteristics of feline infectious peritonitis virus and its growth in autochthonous peritoneal cell cultures. Amer. J. vet. Res. 1976;37:567–572. [PubMed] [Google Scholar]
  • 17.Pedersen N. C. Feline infectious peritonitis: something old, something new. Feline Practice. 1976;6:42–51. [Google Scholar]
  • 18.Pensaert M. B., Callebant P. E. Characteristics of a coronavirus causing vomition and wasting in pigs. Arch. ges. Virusforsch. 1974;44:35–50. doi: 10.1007/BF01242179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Reynolds D. J., Garwes D. J., Gaskell C. J. Detection of transmissible gastroenteritis virus neutralizing antibody in cats. Arch. Virol. 1977;55:77–86. doi: 10.1007/BF01314481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Sharpee R. L. Characterization of a calf diarrheal coronavirus. Lincoln, Nebraska: University of Nebraska; 1976. [PubMed] [Google Scholar]
  • 21.Sharpee R. L., Mebus C. A., Bass E. P. Characterization of a calf diarrheal coronavirus. Amer. J. vet. Res. 1976;37:1031–1041. [PubMed] [Google Scholar]
  • 22.Tajima M. Morphology of transmissible gastroenteritis virus of pigs. Arch. ges. Virusforsch. 1970;29:105–108. doi: 10.1007/BF01253886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Tyrrell D. A. J., Almeida J. D., Cunningham C. H., Dowdle W. R., Hofstad M. S., McIntosh K., Tajima M., Zakstelskaya L. Ya., Easterday B. C., Kapikian A., Bingham R. W. Coronaviridae. Intervirology. 1975;5:76–82. doi: 10.1159/000149883. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Ward J. M. Morphogenesis of a virus in cats with experimental feline infectious peritonitis. Virology. 1970;41:191–194. doi: 10.1016/0042-6822(70)90070-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Witte K. H., Tuch K., Dubenkropp H., Walther C. Untersuchungen über die Antigenverwandtschaft der Viren der Felinen infektiöser Peritonitis und der transmissiblen Gastroenteritis des Schweines. Berl. Münch. Tierärztl. Wschr. 1977;90:396–401. [PubMed] [Google Scholar]
  • 26.Zook B. C., King N. W., Robinson R. L., McCombs H. L. Ultrastructural evidence for the viral etiology of feline infectious peritonitis. Path. Vet. 1968;5:91–95. [Google Scholar]

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