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. 1981;3(4):439–459. doi: 10.1007/BF01951492

Theimunopathogenesis of cronic HBV inducedliver disease

Gary A Levy 1, Francis V Chisari 1,✉
PMCID: PMC7087516  PMID: 6168027

Conclusion

In conclusion, until the cellular biology of hepatitis B virus infection is understood and until the technology for the development of suitable virus infected autologous target cells is available, it will not be possible to definitively establish the mechanism involved in the pathogenesis of hepatitis B virus induced hepatocellular injury. Clearly, considerable effort must now be focused on the basic biology of virus infection, replication, and effects on hepatocellular metabolism before it will be possible to perform the definitive experiments to elucidate the role played by the immune system in the pathogenesis of this disease.

Keywords: Hepatitis, Internal Medicine, Immune System, Virus Infection, Target Cell

References

  • 1.Agarwal SS, Blumberg BB, Gerstley BJS, London WT, Millman I, Sutmek AI, Loeb LA. Lymphocyte transformation and hepatitis. I. Impairment of thymidine incorporation and DNA polymerase activity. Proc Soc Exp Biol Med. 1971;137:1498. doi: 10.3181/00379727-137-35818. [DOI] [PubMed] [Google Scholar]
  • 2.Alberti A, Realdi G, Tremolodi F, Spiver GP. Liver cell surface localization of hepatitis B antigen and immunoglobulins in acute and chronic hepatitis and liver cirrhosis. Clin Exp Immunol. 1976;25:396. [PMC free article] [PubMed] [Google Scholar]
  • 3.Alberti A, Realdi G, Bortolotti F, Rigoli AM. T-lymphocyte cytotoxicity to HBsAg-coated target cells in hepatitis B virus infection. Gut. 1977;18:1004. doi: 10.1136/gut.18.12.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Alexander JJ, Bey EM, Geddes EW, Lecatsas G. Establishment of a continuous growing cell line from primary carcinoma of the liver. S Afr Med J. 1976;50:2124. [PubMed] [Google Scholar]
  • 5.Bang FB, Warwick A. Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis of their susceptibility. Proc Natl Acad Sci USA. 1960;46:1. doi: 10.1073/pnas.46.8.1065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Barker LF, Shulman WR, Murray R, Hirschman RJ, Ratner F, Diefenback WCL, Geller HM. Transmission of serum hepatitis. JAMA. 1970;211:1509. [PubMed] [Google Scholar]
  • 7.Behrens UH, Paronetto F. Studies on liver-specific antigens. 1. Evaluation of the liver specificity of “LSP” and “LP-2”. Gastroenterology. 1979;77:1045. [PubMed] [Google Scholar]
  • 8.Blumberg BS, Sutnick AI, London WT. Australia antigen as a hepatitis virus. Variation in host response. Am J Med. 1970;48:1. doi: 10.1016/0002-9343(70)90093-8. [DOI] [PubMed] [Google Scholar]
  • 9.Le Bouvier GL. The heterogeneity of Australia antigen. J Infect Dis. 1971;123:671. doi: 10.1093/infdis/123.6.671. [DOI] [PubMed] [Google Scholar]
  • 10.Chang RS. Continuous subcultivation of epithelial-like cells from normal tissue. Proc Soc Exp Biol Med. 1954;87:440. doi: 10.3181/00379727-87-21406. [DOI] [PubMed] [Google Scholar]
  • 11.Charpentier B, Guttmann RL, Shuster J, Gold P. Augmentation of proliferation of human mixed lymphocyte culture by human α-fetoprotein. J Immunol. 1977;119:897. [PubMed] [Google Scholar]
  • 12.Chisari FV. Immunoregulatory properties of human plasma in very low density lipoprotein. J Immunol. 1977;119:2129. [PubMed] [Google Scholar]
  • 13.Chisari FV. Regulation of human lymphocyte function by a soluble extract from normal human liver. J. Immunol. 1978;121:1279. [PubMed] [Google Scholar]
  • 14.Chisari FV. Liver-specific protein in perspective. Gastroenterology. 1979;7:168. [PubMed] [Google Scholar]
  • 15.Chisari FV, Anderson DS. Cytotoxic and suppressor cell function in hepatitis. Clin Res. 1979;27:470A. [Google Scholar]
  • 16.Chisari FV, Edginton TS. Lymphocyte E rosette inhibitory factor: a regulatory serum lipoprotein. J Exp Med. 1975;142:1092. doi: 10.1084/jem.142.5.1092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Chisari FV, Routenberg JA, Edgington TS. Mechanisms responsible for defective human T lymphocyte sheep erythrocyte rosette function associated with hepatitis B virus infections. J Clin Invest. 1976;57:1227. doi: 10.1172/JCI108391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Chisari FV, Gealy WJ, Edgington TS. Recovery of soluble sheep eythrocyte receptor from the T lymphocyte surface by proteolytic cleavage. J Immunol. 1977;118:1138. [PubMed] [Google Scholar]
  • 19.Chisari FV, Routenberg JA, Fiala M, Edgington TS. Extrinsic modulation of human T-lymphocyte E rosette function associated with prolonged hepatocellulax injury after viral hepatitis. J Clin Invest. 1977;59:134. doi: 10.1172/JCI108610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Chisari FV, Routenberg JA, Anderson DS, Edgington TS. Cellular immune reactivity in hepatitis B virus-induced liver disease in viral hepatitis. In: Vyas GW, Cohen SW, Schmid R, editors. Viral hepatitis. Philadelphia, PA: Franklin Press; 1978. p. 245. [Google Scholar]
  • 21.Chisari FV, Bieber MS, Josepho CA, Xavier C, Anderson DS. Functional properties of lymphocytes subpopulations in hepatitis B virus infection II. Cytotoxic effector cell killing of targets which naturally express hepatitis B surface antigen and liver specific lipoprotein. J Immunol. 1981;126:45. [PubMed] [Google Scholar]
  • 22.Chisari FV, Castle KL, Xavier C, Anderson DS. Functional properties of lymphocyte subpopulations in hepatitis B virus infection. I. Suppressor cell control of T lymphocyte responsiveness. J Immunol. 1981;126:38. [PubMed] [Google Scholar]
  • 23.Cochrane AMB, Moussouros A, Thomson AD, Eddleston ALWF, Williams R. Antibody dependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis. Lancet. 1976;1:441. doi: 10.1016/s0140-6736(76)91472-0. [DOI] [PubMed] [Google Scholar]
  • 24.Colombo M, Vernace SJ, Paronetto F. T and B lymphocytes in patients with chronic active hepatitis. Clin Exp Immunol. 1977;30:4. [PMC free article] [PubMed] [Google Scholar]
  • 25.Dehoratius RJ, Strickland RG, Williams RC. T and B lymphocytes in acute and chronic hepatitis. Clin Immunol Immunopathol. 1974;2:353. doi: 10.1016/0090-1229(74)90053-1. [DOI] [PubMed] [Google Scholar]
  • 26.Doherty PC, Gotze D, Trinchieri G, Zinkernagel RM. Models for recognition of virally modified cells by immune thymus-derived lymphocytes. Immunogenetics. 1976;3:517. [Google Scholar]
  • 27.Doherty PC, Solert D, Knowles BB. H-2 gene expression is required for T cell-mediated lysis of virus-infected target cells. Nature. 1977;266:361. doi: 10.1038/266361a0. [DOI] [PubMed] [Google Scholar]
  • 28.Dudley FJ, Fox RA, Sherlock S. Relationship of hepatitis associated antigen (H.A.A.) to acute and chronic liver injury. Lancet. 1971;I:12. doi: 10.1016/s0140-6736(71)90001-8. [DOI] [PubMed] [Google Scholar]
  • 29.Dudley FJ, Fox RA, Sherlock S. Cellular immunity and hepatitis-associated Australia antigen liver disease. Lancet. 1972;1:723. doi: 10.1016/s0140-6736(72)90234-6. [DOI] [PubMed] [Google Scholar]
  • 30.Dudley FJ, Giustino V, Sherlock S. Cell mediated immunity in patients positive for hepatitis associated antigen. Br Med J. 1972;4:754. doi: 10.1136/bmj.4.5843.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31.Eddleston ALWF (1975) Lymphocyte cytotoxicity to isolated hepatocytes in active chronic hepatitis. The role of T and B cells. Chronic Hepatitis International Symposium Montecatini, Italy p 117
  • 32.Eddleston ALWF, Williams R. The role of immunological mechanisms in chronic hepatitis. Ann Clin Res. 1976;8:162. [PubMed] [Google Scholar]
  • 33.Edgington TS, Chisari FV. Immunologic aspects of hepatitis B virus infection. Am J Med Sci. 1975;270:213. [PubMed] [Google Scholar]
  • 34.Edginton TS, Chisari FV, Curtiss LK. Immunopathology International Symposium. Basel/Stuttgart: Schwabe and Co; 1976. Regulation of lymphocyte function in HBV infection; p. 173. [Google Scholar]
  • 35.Edgington TS, Curtiss LK, DeHeer DH. Immunoregulatory characteristics of LDL-In a species of normal low density lipoprotein. Clin Res. 1976;24:445. [Google Scholar]
  • 36.Edginton TS, Henney CH, Curtiss LK. The bioregulatory properties of the low density lipoprotein inhibitor (LDL-In) on the generation of killer T cells. In: Miescher PA, editor. Proceedings of the 11th Leukocyte Culture Conference. Basel/Stuttgart: Schwabe and Co; 1976. p. 173. [Google Scholar]
  • 37.El Sheikh N, Osman CG, Cullens H, Eddleston ALWF, Williams R. T lymphocyte-mediated cytotoxicity in HB,Ag positive liver disease. Clin Exp Immunol. 1978;31:158. [PMC free article] [PubMed] [Google Scholar]
  • 38.Facchini A, Stefanni GF, Bernardi M, Miglio F, Gasbarini G, Labo G. Lymphocytotoxicity test against rabbit hepatocytes in chronic liver diseases. Gut. 1978;19:189. doi: 10.1136/gut.19.3.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 39.Fernandez-Cruz E, Escartin P, Bootello A, Kreisler H, Segovia De Arana JM. Hepatocyte damage induced by lymphocytes from patients with chronic liver diseases as detected by LDH release. Clin Exp Immunol. 1978;31:436. [PMC free article] [PubMed] [Google Scholar]
  • 40.Gershon RK. T cell control of antibody production. Contemp Top Immunol. 1974;3:1. doi: 10.1007/978-1-4684-3045-5_1. [DOI] [PubMed] [Google Scholar]
  • 41.Gershon RK, Kondo K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology. 1970;18:723. [PMC free article] [PubMed] [Google Scholar]
  • 42.Girmann G, Pees H, Shwartze G, Scheurlen PG. Immunosuppression by micromolecular fibrinogen degradation products in cancer. Nature. 1976;259:399. doi: 10.1038/259399a0. [DOI] [PubMed] [Google Scholar]
  • 43.Gocke DJ. Extrahepatic manifestations of viral hepatitis. Am J Med Sci. 1975;270:49. doi: 10.1097/00000441-197507000-00007. [DOI] [PubMed] [Google Scholar]
  • 44.Good RA, Page AR. Fatal complications of virus hepatitis in two patients with agammaglobulinemia. Am J Med. 1960;29:804. doi: 10.1016/0002-9343(60)90114-5. [DOI] [PubMed] [Google Scholar]
  • 45.Ha TY, Waksman BH. Role of the thymus in tolerance X. Suppressor activity of antigenstimulated rat thymocytes transferred to normal recipients. J Immunol. 1973;110:1290. [PubMed] [Google Scholar]
  • 46.Hodgson HJF, Wands JR, Isselbacher KJ. Alteration in suppressor cell activity in chronic active hepatitis. Proc Natl Acad Sci USA. 1978;75:1549. doi: 10.1073/pnas.75.3.1549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 47.Hopf U, Meyer Zum Buschenfelde KH, Freudenberg J. Liver specific antigens of different species. II. Localization of a membrane antigen at cell surface of isolated hepatocytes. Clin Exp Immunol. 1974;16:117. [PMC free article] [PubMed] [Google Scholar]
  • 48.Ibrahim AB, Vyas GN, Perkins HA. Immune response to hepatitis B surface antigen. Infect Immun. 1975;11:137. doi: 10.1128/iai.11.1.137-141.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 49.Jensen DM, McFarlane IG, Portmann BS, Eddleston ALWF, Williams R. Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis. N Engl J Med. 1978;299:1. doi: 10.1056/NEJM197807062990101. [DOI] [PubMed] [Google Scholar]
  • 50.Joseph BS, Oldstone MBA. Antibody induced redistribution of measles virus antigens on the cell surface. J Immunol. 1975;113:1205. [PubMed] [Google Scholar]
  • 51.Kakumu S, Hara T, Goku H, Sakamoto N. Lymphocyte cytotoxicity against Chang liver cells in chronic active hepatitis. Cell Immunol. 1978;36:46. doi: 10.1016/0008-8749(78)90249-6. [DOI] [PubMed] [Google Scholar]
  • 52.Kongshaven PAL, Hawkins D, Shuster J. The biology of the immune response. In: Freedman SO, Gold P, editors. Clinical immunology. Maryland: Harper and Row; 1976. p. 1. [Google Scholar]
  • 53.Krugman S, Giles JK. Viral hepatitis: new light on an old disease. JAMA. 1970;212:1019. doi: 10.1001/jama.212.6.1019. [DOI] [PubMed] [Google Scholar]
  • 54.Laughter AH, Twomey JJ. Suppression of lymphoproliferation by high concentrations of normal human mononuclear leukocytes. J Immunol. 1977;119:173. [PubMed] [Google Scholar]
  • 55.Lee WM, Reed WP, Mitchell CG, Galbraith RM, Eddleston ALWF, Zuckerman AJ, Williams R. Cellular and humoral immunity to hepatitis B surface antigen in active chronic hepatitis. Br Med J. 1975;1:705. doi: 10.1136/bmj.1.5960.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 56.Lee WM, Reed WD, Osman CG, Vahrman J, Zuckerman AJ, Eddleston ALWF, Williams R. Immune responses to the hepatitis B surface antigen and liver specific lipoprotein in acute type B hepatitis. Gut. 1977;18:250. doi: 10.1136/gut.18.3.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 57.Levo Y. Extrahepatic manifestations of hepatitis B virus infection. Isr J Med Sci. 1979;15:726. [PubMed] [Google Scholar]
  • 58.Levy GA, Edgington TS. Lymphocyte collaboration is required for the generation of procoagulant activity. J Exp Med. 1980;151:1232. doi: 10.1084/jem.151.5.1232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 59.Magnius LO, Espmark JA. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants. J Immunol. 1972;109:1017. [PubMed] [Google Scholar]
  • 60.McFarlane G, Wojcicka BM, Zucker GM, Eddleston ALWF, Williams R. Purification and characterization of human liver-specific membrane lipoprotein (LSP) Clin Exp Immunol. 1977;27:381. [PMC free article] [PubMed] [Google Scholar]
  • 61.Melnick JL, Dreesman GR, Hollinger FB. Viral hepatitis. Scientific American. 1977;44:237. doi: 10.1038/scientificamerican0777-44. [DOI] [PubMed] [Google Scholar]
  • 62.Meyer Zum Buschenfelde KH, Hopf U. Studies of the pathogenesis of experimental chronic active hepatitis in rabbits. 1. Induction of the disease and protective effect of allogeneic liver specific proteins. Br J Exp Pathol. 1974;55:498. [PMC free article] [PubMed] [Google Scholar]
  • 63.Meyer Zum Buschenfelde KB, Meixcher PA. Liver specific antigens. Purification and characterization. Clin Exp Immunol. 1972;10:89. [PMC free article] [PubMed] [Google Scholar]
  • 64.Meyer Zum Buschenfelde KH, Kossling FK, Miescher PA. Experimental chronic active hepatitis in rabbits following immunization with human liver proteins. Clin Exp Immunol. 1972;10:99. [PMC free article] [PubMed] [Google Scholar]
  • 65.Meyer Zum Buschenfelde KH, Alberti A, Arnold W, Freudenberg J. Organ specificity and diagnostic value of cell mediated immunity against a liver-specific membrane protein: Studies in hepatic and non-hepatic diseases. Klin Wochenschr. 1975;53:1061. doi: 10.1007/BF01614382. [DOI] [PubMed] [Google Scholar]
  • 66.Miller KB, Schwartz RS. Familial abnormalities of suppressor cell function in systemic lupus erythematosus. N Engl J Med. 1979;301:803. doi: 10.1056/NEJM197910113011502. [DOI] [PubMed] [Google Scholar]
  • 67.Miller J, Smith MGM, Mitchell CG, Reed WD, Eddleston ALWF, Williams R. Cell mediated immunity to a liver specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet. 1972;2:296. doi: 10.1016/s0140-6736(72)92904-2. [DOI] [PubMed] [Google Scholar]
  • 68.Miller DJ, Duyer JM, Klatskin G. Identification of lymphocytes in percutaneous liver biopsy cores. Gastroenterology. 1977;72:1199. [PubMed] [Google Scholar]
  • 69.Miyakawa Y, Mayumi M. Characterization and clinical significance of HBcAg. In: Vyas G, Cohen SN, Schmid R, editors. Viral hepatitis. Philadelphia: The Franklin Institute Press; 1978. p. 193. [Google Scholar]
  • 70.Mogensen SC. Role of macrophages in natural resistance to virus infection. Microbiol Rev. 1979;43:1. doi: 10.1128/mr.43.1.1-26.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 71.Moretta L, Webb SR, Grossi CE, Lydyard PM, Cooper DM. Functional analysis of two human T cell subpopulations: help and suppression of B cell responses by T cells bearing receptor for IgM and IgG. J Exp Med. 1977;146:184. doi: 10.1084/jem.146.1.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 72.Mortensen RF, Osmand AP, Gewarz H. Effects of C. reactive protein on the lymphoid system. J Exp Med. 1975;141:821. [PMC free article] [PubMed] [Google Scholar]
  • 73.Nelson DL, Bundy BM, Pitchon HE, Blaese RM, Strober W. The effector cells in human peripheral blood mediating mitogen induced cellular cytotoxicity and antibody dependent cellular cytotoxicity. J Immunol. 1976;117:1472. [PubMed] [Google Scholar]
  • 74.Neurath AR, Strick N. Host specificity of a serum marker for hepatitis B: Evidence that “e antigen” has the properties of an immunoglobulin. Proc Natl Acad Sci USA. 1977;74:1702. doi: 10.1073/pnas.74.4.1702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 75.Nowolaski A, Krawczynski T, Nazarewicsz T, Scusarcyzk Y. Immunologic aspects of hepatitis B virus infection. Am J Med Sci. 1975;270:229. [Google Scholar]
  • 76.Paronetto F, Vernace S. Immunological studies in patients with chronic active hepatitis. Clin Exp Immunol. 1975;19:99. [PMC free article] [PubMed] [Google Scholar]
  • 77.Pfizemaier K, Trostman H, Rollinghoff M, Wagner H. Cell mediated immunity in lymphocytic choriomeningitis I. The specificty of cytotoxic lymphocytes. Z Immunitaetsforsch. 1976;151:224. [PubMed] [Google Scholar]
  • 78.Redeker AG. Viral hepatitis: Clinical aspects. Am J Med Sci. 1975;270:9. doi: 10.1097/00000441-197507000-00003. [DOI] [PubMed] [Google Scholar]
  • 79.Sabesin SM, Koff RS. Pathogenesis of experimental viral hepatitis. N Engl J Med. 1974;290:944. doi: 10.1056/NEJM197405022901805. [DOI] [PubMed] [Google Scholar]
  • 80.Sakane T, Green I. Human suppressor T cells induced by concanavalin A: suppressor T cells belong to distinctive T cell subclasses. J Immunol. 1977;119:1169. [PubMed] [Google Scholar]
  • 81.Seidel D, Alaupovic P, Furman RH. A lipoprotein characterizing obstructive jaundice, method for quantitative separation and identification of lipoproteins in jaundiced subjects. J Clin Invest. 1969;48:1211. doi: 10.1172/JCI106085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 82.Sell S, Skelly H, Leffert HL, Mueller-Eberhard W, Kida S. Relationship of the Biosynthesis of a fetoprotein, albumin, hemopexin and haptoglobin to the growth state of fetal rat hepatocyte cultures. Ann NY Acad Sci. 1975;259:45. doi: 10.1111/j.1749-6632.1975.tb25401.x. [DOI] [PubMed] [Google Scholar]
  • 83.Shif 1, Bang FB. In vitro interaction of mouse hepatitis virus and macrophages from genetically resistant mice. I. Adsorption of virus and growth curves. J Exp Med. 1970;131:843. doi: 10.1084/jem.131.4.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 84.Sorrell MF, Leevy CM. Lymphocyte transformation and alcoholic liver injury. Gastroenterology. 1972;63:1020. [PubMed] [Google Scholar]
  • 85.Stevens JG, Cook ML. Maintenance of latent herpetic infection: an apparent role for anti-viral IgG. J Immunol. 1974;113:1685. [PubMed] [Google Scholar]
  • 86.Tavassolie H, Kawanishi H. Serum factors inhibition of lymphocyte proliferation and suppressor T cell function in alcoholic and chronic active liver disease. Gastroenterology. 1978;75:990. [Google Scholar]
  • 87.Tomasi TB. Serum factors which suppress the immune response. In: Lucas DO, editor. regulatory mechanisms in lymphocyte activation. New York: Academic Press; 1977. p. 219. [Google Scholar]
  • 88.Tong MJ, Wallace AM, Peters RL, Reynolds TB. Lymphocyte stimulation in hepatitis B infections. N Engl J Med. 1975;293:318. doi: 10.1056/NEJM197508142930702. [DOI] [PubMed] [Google Scholar]
  • 89.Vierling JM, Nelson PK, Strober W, Bundy BM, Jones EA. In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis, Dysfunction of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis. J Clin Invest. 1977;60:1116. doi: 10.1172/JCI108863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 90.Vogten AJM, Hadzic N, Shorter RG, Summerskill WHJ, Taylor WF. Cell-mediated cytotoxicity in chronic active liver disease: A new test system. Gastroenterology. 1978;74:883. [PubMed] [Google Scholar]
  • 91.Wands JR, Isselbacher FJ. Lymphocyte cytotoxicity to autologous liver cells in chronic active hepatitis. Proc Natl Acad Sci USA. 1975;72:1301. doi: 10.1073/pnas.72.4.1301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 92.Wands JR, Perrotto JL, Alpert E, Isselbacher KJ. Cell-mediated immunity in acute and chronic hepatitis. J Clin Invest. 1975;55:921. doi: 10.1172/JCI108021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 93.Warnatz H, Rosch W, Gerlich W, Gutmann W. Antibody-dependent cell-mediated cytotoxicity to HBsAg coated target cells in patients with hepatitis B and chronic hepatitis (CAH) Clin Exp Immunol. 1979;35:133. [PMC free article] [PubMed] [Google Scholar]
  • 94.Williams R, Eddleston ALWF. Chronic active hepatitis: Immunopathogenesis and immunotherapy. Isr J Med Sci. 1979;15:261. [PubMed] [Google Scholar]
  • 95.Zinkernagel RM, Doherty PC. Restriction of in vitro T cell mediated cytotoxicity in lymphocyte choriomeningitis within a synergeneic or semiallogeneic system. Nature. 1974;248:702. doi: 10.1038/248701a0. [DOI] [PubMed] [Google Scholar]

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