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. 1985;8(3):197–208. doi: 10.1007/BF00197296

Relapsing experimental allergic encephalomyelitis an autoimmune model of multiple sclerosis

Fred D Lublin 1
PMCID: PMC7087536  PMID: 3931271

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References

  • 1.Ben-Nun A, Cohen IR. Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: Process of selection of lines and characterization of the cells. J Immunol. 1982;129:303. [PubMed] [Google Scholar]
  • 2.Bernard CCA. Suppressor T cells prevent experimental autoimmune encephalomyelitis in mice. Clin Exp Immunol. 1977;29:100. [PMC free article] [PubMed] [Google Scholar]
  • 3.Bernard CCA, Mackay IR. Transfer of murine experimental autoimmune encephalomyelitis and cell-mediated immunity to myelin protein is effected by Lyt-1 cells. J Neuroimmunol. 1983;4:61. doi: 10.1016/0165-5728(83)90064-4. [DOI] [PubMed] [Google Scholar]
  • 4.Bernard CCA, Leydon J, Mackay IR. T cell necessity in the pathogenesis of experimental autoimmune encephalomyelitis in mice. Eur J Immunol. 1976;6:655. doi: 10.1002/eji.1830060912. [DOI] [PubMed] [Google Scholar]
  • 5.Brown AM, McFarlin DE. Relapsing experimental allergic encephalomyelitis in the SJL/J mouse. Lab Invest. 1981;45:278. [PubMed] [Google Scholar]
  • 6.Brown AM, McFarlin DE, Raine CS. Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse. Lab Invest. 1982;46:171. [PubMed] [Google Scholar]
  • 7.Cambi F, Less MB, Williams RM, Macklin WB. Chronic experimental allergic encephalomyelitis produced by bovine proteolipid apoprotein: Immunological studies in rabbits. Ann Neurol. 1983;13:303. doi: 10.1002/ana.410130313. [DOI] [PubMed] [Google Scholar]
  • 8.Ferraro A, Cazzullo CL. Chronic allergic encephalomyelitis in monkeys. J Neuropathol Exp Neurol. 1948;7:235. doi: 10.1097/00005072-194807000-00001. [DOI] [PubMed] [Google Scholar]
  • 9.Fritz RB, Chou CH, McFarlin DE. Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein. J Immunol. 1983;130:1024. [PubMed] [Google Scholar]
  • 10.Hayreh SS, Massanari RM, Yamada T, Hayreh SM. Experimental allergic encephalomyelitis. I. Optic nerve and central nervous system manifestations. Invest Ophthalmol Vis Sci. 1981;21:259. [PubMed] [Google Scholar]
  • 11.Huddlestone JR, Oldstone MB. T suppressor (TG) lymphocytes flucuate in parallel with changes in the clinical course of patients with multiple sclerosis. J Immunol. 1979;123:1615. [PubMed] [Google Scholar]
  • 12.Johnson RT, Griffin DE, Hirsch RL, Wolinsky JS, Roedenbeck S, De Soriano L, Vaisberg A. Measles encephalomyelitis — clinical and immunopathologic studies. N Engl J Med. 1984;310:137. doi: 10.1056/NEJM198401193100301. [DOI] [PubMed] [Google Scholar]
  • 13.Karcher D, Lassmann H, Lowenthal A, Kitz K, Wisniewski HM. Antibodies-restricted heterogeneity in serum and cerebrospinal fluid of chronic relapsing experimental allergic encephalomyelitis. J Immunol. 1982;2:93. doi: 10.1016/0165-5728(82)90001-7. [DOI] [PubMed] [Google Scholar]
  • 14.Keith AB, McDermott JR. Optimum conditions for inducing chronic relapsing experimental allergic encephalomyelitis in guinea pigs. J Neurol Sci. 1980;46:353. doi: 10.1016/0022-510x(80)90060-x. [DOI] [PubMed] [Google Scholar]
  • 15.Keith AB, Arnon R, Teitelbaum D, Caspary EA, Wisniewski HM. The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs. J Neurol Sci. 1979;42:267. doi: 10.1016/0022-510x(79)90058-3. [DOI] [PubMed] [Google Scholar]
  • 16.Kurtzke JF. Epidemiologic contributions to multiple sclerosis — an overview. Neurology. 1980;30:61. doi: 10.1212/wnl.30.7_part_2.61. [DOI] [PubMed] [Google Scholar]
  • 17.Lando Z, Ben-Nun A. Experimental autoimmune encephalomyelitis mediated by T-cell line; II. Specific requirements and the role of pertussis vaccine for the in vitro activation of the cells and induction of disease. Clin Immunol Immunopathol. 1984;30:290. doi: 10.1016/0090-1229(84)90063-1. [DOI] [PubMed] [Google Scholar]
  • 18.Lando Z, Teitelbaum D, Arnon R. Effect of cyclophosphamide on suppressor cell activity in mice unresponsive to EAE. J Immunol. 1979;123:2156. [PubMed] [Google Scholar]
  • 19.Lando Z, Teitelbaum D, Arnon R. Induction of experimental allergic encephalomyelitis in genetically resistant strains of mice. Nature. 1980;287:551. doi: 10.1038/287551a0. [DOI] [PubMed] [Google Scholar]
  • 20.Lassmann H. Chronic relapsing experimental allergic encephalomyelitis: Its value as an experimental model for multiple sclerosis. J Neurol. 1983;229:207. doi: 10.1007/BF00313549. [DOI] [PubMed] [Google Scholar]
  • 21.Lassmann H, Wisniewski HM. Chronic relapsing experimental allergic encephalomyelitis: Effect of age at the time of sensitization on clinical course and pathology. Acta Neuropathol. 1979;47:111. doi: 10.1007/BF00717033. [DOI] [PubMed] [Google Scholar]
  • 22.Lassmann H, Wisniewski HM. Chronic relapsing experimental allergic encephalomyelitis: Clinicopathological comparison with multiple sclerosis. Arch Neurol. 1979;36:490. doi: 10.1001/archneur.1979.00500440060011. [DOI] [PubMed] [Google Scholar]
  • 23.Lassmann H, Kitz K, Wisniewski HM. Structural variability of demyelinating lesions in different models of subacute and chronic experimental allergic encephalomyelitis. Acta Neuropathol. 1980;51:191. doi: 10.1007/BF00687386. [DOI] [PubMed] [Google Scholar]
  • 24.Lassmann H, Kitz K, Wisniewski HM. In vivo effect of sera from animals with chronic relapsing experimental allergic encephalomyelitis on central and peripheral myelin. Acta Neuropathol. 1981;55:297. doi: 10.1007/BF00690994. [DOI] [PubMed] [Google Scholar]
  • 25.Lassmann H, Kitz K, Wisniewski HM. The development of periventricular lesions in chronic relapsing experimental allergic encephalomyelitis in guinea pigs: A light and scanning electron microscopic study. Neuropathol Appl Neurobiol. 1981;7:1. doi: 10.1111/j.1365-2990.1981.tb00227.x. [DOI] [PubMed] [Google Scholar]
  • 26.Lassmann H, Kitz K, Wisniewski HM. Histogenesis of demyelinating lesions in the spinal cord of guinea pigs with chronic relapsing experimental allergic encephalomyelitis. J Neurol Sci. 1981;50:109. doi: 10.1016/0022-510x(81)90046-0. [DOI] [PubMed] [Google Scholar]
  • 27.Lassmann H, Stemberger H, Kitz K, Wisniewski HM. In vivo demyelinating activity of sera from animals with chronic experimental allergic encephalomyelitis. Antibody nature of the demyelinating factor and the role of complement. J Neurol Sci. 1983;59:123. doi: 10.1016/0022-510x(83)90086-2. [DOI] [PubMed] [Google Scholar]
  • 28.Lassmann H, Suchanek G, Kitz K, Stemberger H, Schwerer B, Bernheimer H. Experimental allergic encephalomyelitis: a useful model for multiple sclerosis. New York: Alan R. Liss; 1984. Antibodies in the pathogenesis of demyelination in chronic relapsing EAE (cr-EAE) p. 165. [PubMed] [Google Scholar]
  • 29.Linthicum DS. Development of acute autoimmune encephalomyelitis in mice: Factors regulating the effector phase of the disease. Immunobiology. 1982;162:211. doi: 10.1016/S0171-2985(11)80001-X. [DOI] [PubMed] [Google Scholar]
  • 30.Lisak RP, Behan PO, Zweiman B, Shetty T. Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. Neurology. 1974;24:560. doi: 10.1212/wnl.24.6.560. [DOI] [PubMed] [Google Scholar]
  • 31.Lublin FD. Delayed, relapsing experimental allergic encephalomyelitis in mice. Role of adjuvants and pertussis vaccine. J Neurol Sci. 1982;57:105. doi: 10.1016/0022-510x(82)90114-9. [DOI] [PubMed] [Google Scholar]
  • 32.Lublin FD. Role of myelin antigens in murine relapsing experimental allergic encephalomyelitis. J Clin Lab Immunol. 1984;13:179. [PubMed] [Google Scholar]
  • 33.Lublin FD. Immunomodulation of relapsing experimental allergic encephalomyelitis. Neurology. 1984;34:1615. doi: 10.1212/wnl.34.12.1615. [DOI] [PubMed] [Google Scholar]
  • 34.Lublin FD. Adoptive transfer of murine relapsing experimental allergic encephalomyelitis. Ann Neurol. 1985;17:188. doi: 10.1002/ana.410170214. [DOI] [PubMed] [Google Scholar]
  • 35.Lublin FD, Maurer PH, Berry RG, Tippett D. Delayed, relapsing experimental allergic encephalomyelitis in mice. J Immunol. 1981;126:819. [PubMed] [Google Scholar]
  • 36.Lublin FD, Tippett DL, Maurer PM. Central nervous system and blood lymphocytes in experimental allergic encephalomyelitis. J Clin Lab Immunol. 1983;10:139. [PubMed] [Google Scholar]
  • 37.Madrid RE, Wisniewski HM, Iqbal K, Pullarkat RK, Lassmann H. Relapsing experimental allergic encephalomyelitis induced with isolated myelin and with myelin basic protein plus myelin lipids. J Neurol Sci. 1981;50:399. doi: 10.1016/0022-510x(81)90152-0. [DOI] [PubMed] [Google Scholar]
  • 38.Massanari RM. A latent-relapsing neuroimmune disease in Syrian hamsters. Clin Immunol Immunopathol. 1980;16:211. doi: 10.1016/0090-1229(80)90205-6. [DOI] [PubMed] [Google Scholar]
  • 39.Mehta PD, Lassmann H, Wisniewski HM. Immunologic studies of chronic relapsing EAE in guinea pigs: Similarities to multiple sclerosis. J Immunol. 1981;127:334. [PubMed] [Google Scholar]
  • 40.Mokhtarian F, McFarlin DE, Raine CS. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature. 1984;309:356. doi: 10.1038/309356a0. [DOI] [PubMed] [Google Scholar]
  • 41.Olsson T, Kristensson K, Leijon G, Link H. Demonstration of serum IgG antibodies against myelin during the course of relapsing experimental allergic encephalomyelitis in guinea pigs. J Neurol Sci. 1982;54:359. doi: 10.1016/0022-510x(82)90200-3. [DOI] [PubMed] [Google Scholar]
  • 42.Panitch H, Ciccone C. Induction of recurrent experimental allergic encephalomyelitis with myelin basic protein. Ann Neurol. 1981;9:433. doi: 10.1002/ana.410090504. [DOI] [PubMed] [Google Scholar]
  • 43.Pettinelli CB, McFarlin DE. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein — requirement for Lyt-1+2- T lymphocytes. J Immunol. 1981;127:1420. [PubMed] [Google Scholar]
  • 44.Ravkina L, Rogova V, Lazarenko L. Chronic experimental allergic encephalomyelitis in rhesus monkeys and its modification by treatment. J Neurol Sci. 1978;38:281. doi: 10.1016/0022-510x(78)90136-3. [DOI] [PubMed] [Google Scholar]
  • 45.Schwartz G, Sriram S, Steinman L. Monoclonal anti I-A antibody induces suppressor T cell for myelin basic protein immune responses. Neurology. 1983;33(2):106. [Google Scholar]
  • 46.Sriram S, Steinman L. Anti I-A antibody suppresses active encephalomyelitis: Treatment model for diseases linked to IR genes. J Exp Med. 1983;158:1362. doi: 10.1084/jem.158.4.1362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 47.Stone S, Lerner E. Chronic disseminated allergic encephalomyelitis in guinea pigs. Ann NY Acad Sci. 1965;122:227. doi: 10.1111/j.1749-6632.1965.tb20206.x. [DOI] [PubMed] [Google Scholar]
  • 48.Suckling AJ, Reiber H, Kirby JA, Rumsby MG. Chronic relapsing experimental allergic encephalomyelitis. Immunological and blood-cerebrospinal fluid barrier-dependent changes in the cerebrospinad fluid. J Neuroimmunol. 1983;4:35. doi: 10.1016/0165-5728(83)90062-0. [DOI] [PubMed] [Google Scholar]
  • 49.Tabira T, Itoyama Y, Kuriowa Y. Chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs: Presence of myelin basic protein in the local tissue long after the immunization. Jpn J Exp Med. 1982;52:131. [PubMed] [Google Scholar]
  • 50.Traugott U, Stone SH, Raine CS. Experimental allergic encephalomyelitis — T cell migration to the central nervous system. J Neurol Sci. 1978;36:55. doi: 10.1016/0022-510x(78)90161-2. [DOI] [PubMed] [Google Scholar]
  • 51.Traugott U, Stone SH, Raine CS. Chronic relapsing experimental allergic encephalomyelitis. Correlation of circulating lymphocyte fluctuations with disease activity in suppressed and unsuppressed animals. J Neurol Sci. 1979;41:17. doi: 10.1016/0022-510x(79)90136-9. [DOI] [PubMed] [Google Scholar]
  • 52.Traugott U, Shevach E, Chiba J, Stone SH, Raine CS. Chronic relapsing experimental allergic encephalomyelitis: Identification and dynamics of T and B cells within the central nervous system. Cell Immunol. 1982;68:261. doi: 10.1016/0008-8749(82)90111-3. [DOI] [PubMed] [Google Scholar]
  • 53.Traugott U, Stone SH, Raine CS. Chronic relapsing experimental autoimmune encephalomyelitis treatment with combinations of myelin components promotes clinical and structural recovery. J Neurol Sci. 1982;56:65. doi: 10.1016/0022-510x(82)90061-2. [DOI] [PubMed] [Google Scholar]
  • 54.Traugott U, Reinherz EL, Raine C. Multiple sclerosis: Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages. J Neuroimmunol. 1983;4:201. doi: 10.1016/0165-5728(83)90036-x. [DOI] [PubMed] [Google Scholar]
  • 55.Trotter JL, Clark HB. Contamination of proteolipid protein with basic protein. Ann Neurol. 1984;16:514. doi: 10.1002/ana.410160417. [DOI] [PubMed] [Google Scholar]
  • 56.Watanabe R, Wege H, ter-Meulen V. Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demylinating encephalomyelitis. Nature. 1983;305:150. doi: 10.1038/305150a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 57.Williams RM, Less MD, Cambi F, Macklin WB. Chronic experimental allergic encephalomyelitis induced in rabbits with bovine white matter proteolipid apoprotein. J Neuropathol Exp Neurol. 1982;41:508. doi: 10.1097/00005072-198209000-00004. [DOI] [PubMed] [Google Scholar]
  • 58.Wisniewski HM, Keith AB. Chronic relapsing experimental allergic encephalomyelitis — an experimental model of multiple sclerosis. Ann Neurol. 1977;1:144. doi: 10.1002/ana.410010207. [DOI] [PubMed] [Google Scholar]
  • 59.Wisniewski HM, Madrid RE. Chronic progressive experimental allergic encephalomyelitis (EAE) in adult guinea pigs. J Neuropathol Exp Neurol. 1983;42:243. doi: 10.1097/00005072-198305000-00003. [DOI] [PubMed] [Google Scholar]

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