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. 2011 Jan 19;73(1):1–13. doi: 10.1134/S000629790801001X

Cysteine proteinases of microorganisms and viruses

G N Rudenskaya 1,✉, D V Pupov 2
PMCID: PMC7087786  PMID: 18294123

Abstract

This review considers properties of secreted cysteine proteinases of protozoa, bacteria, and viruses and presents information on the contemporary taxonomy of cysteine proteinases. Literature data on the structure and physicochemical and enzymatic properties of these enzymes are reviewed. High interest in cysteine proteinases is explained by the discovery of these enzymes mostly in pathogenic organisms. The role of the proteinases in pathogenesis of several severe diseases of human and animals is discussed.

Key words: cysteine proteinases, properties, protozoa, bacteria, viruses

Abbreviations

DTT

dithiothreitol

FMDV

foot-and-mouth disease virus

RDRP

RNA-dependent RNA polymerase

TLCK

tosyl-L-lysine chloromethyl ketone

TPCK

tosyl-L-phenylalanine chloromethyl ketone

Footnotes

Original Russian Text © G. N. Rudenskaya, D. V. Pupov, 2008, published in Biokhimiya, 2008, Vol. 73, No. 1, pp. 3–17.

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