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. 2008 Sep 21;73(9):957–964. doi: 10.1134/S0006297908090010

Aconitate hydratase of mammals under oxidative stress

L V Matasova 1,✉, T N Popova 1
PMCID: PMC7087844  PMID: 18976211

Abstract

Data on the structure, functions, regulation of activity, and expression of cytosolic and mitochondrial aconitate hydratase isoenzymes of mammals are reviewed. The role of aconitate hydratase and structurally similar iron-regulatory protein in maintenance of homeostasis of cell iron is described. Information on modifications of the aconitate hydratase molecule and changes in expression under oxidative stress is generalized. The role of aconitate hydratase in the pathogenesis of some diseases is considered.

Key words: aconitase, citrate, oxidative stress, iron, iron-regulatory proteins, regulation of activity and expression

Abbreviations

AH

aconitate hydratase

cAH

cytoplasmic aconitase isoenzyme

HRM

hemoregulatory motif

IL

interleukins

IRE

iron-sensitive elements

IRP

iron-regulatory proteins

LIP

labile iron pool

mAH

mitochondrial aconitase isoenzyme

MtFt

mitochondrial ferritin

ROS

reactive oxygen species

SOD

superoxide dismutase

TCA cycle

tricarboxylic acid cycle

TNF-α

tumor necrosis factor-α

Footnotes

Original Russian Text © L. V. Matasova, T. N. Popova, 2008, published in Biokhimiya, 2008, Vol. 73, No. 9, pp. 1189–1198.

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