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. 1988;235(4):229–233. doi: 10.1007/BF00314352

Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis

R Martin 1,✉, U Martens 1, V Sticht-Groh 2, R Dörries 3, H Krüger 1
PMCID: PMC7088014  PMID: 3373242

Summary

In the cerebrospinal fluid IgG of five patients with lymphomeningoradiculitis (Bannwarth's syndrome) and radiculomyelitis studied by immunoblot technique an oligoclonal pattern was found. Most of these oligoclonal bands were specific for Borrelia burgdorferi. In patients suffering from chronic meningoradiculomyelitis, repeated CSF examination by this technique showed persistent secretion of identical IgG bands. Thus, the specific humoral immune response and the disease activity could be documented over the course of the disease.

Key words: Lyme disease, Lymphomeningoradiculitis, Borrelia burgdorferi, Cerebrospinal fluid, Immunoblot technique

References

  • 1.Ackermann R, Gollmer E, Rehse-Küpper B. Progressive Borrelien-Enzephalomyelitis. Dtsch Med Wochenschr. 1985;110:1039–1042. doi: 10.1055/s-2008-1068956. [DOI] [PubMed] [Google Scholar]
  • 2.Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP. Lyme disease, a tick-borne spirochetosis? Science. 1982;216:1317–1319. doi: 10.1126/science.7043737. [DOI] [PubMed] [Google Scholar]
  • 3.Col F, Bruhn W. Lyme disease. Am J Dis Child. 1984;138:467–470. doi: 10.1001/archpedi.1984.02140430045011. [DOI] [PubMed] [Google Scholar]
  • 4.Craft JE, Grodzicki RL, Steere AC. Antibody response in Lyme disease: evaluation of diagnostic tests. J Infect Dis. 1984;149:789–795. doi: 10.1093/infdis/149.5.789. [DOI] [PubMed] [Google Scholar]
  • 5.Delpech B, Lichtblau E. Etude quantitative des immunoglubulines G et de l'albumine du liquide cephalorachidien. Clin Chim Acta. 1972;37:15–23. doi: 10.1016/0009-8981(72)90410-x. [DOI] [PubMed] [Google Scholar]
  • 6.Dörries R, ter Meulen V. Detection and identification of virus-specific, oligoclonal IgG in unconcentrated cerebrospinal fluid by immoblot technique. J Neuroimmunol. 1984;7:77–89. doi: 10.1016/s0165-5728(84)80008-9. [DOI] [PubMed] [Google Scholar]
  • 7.Dörries R, Watanabe R, Wege H, ter Meulen V. Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine corona-virus JHM. J Neuroimmunol. 1987;14:305–316. doi: 10.1016/0165-5728(87)90017-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Henriksson A, Link H, Cruz M, Stiernstedt G. Immunoglobulin abnormalities in cerebrospinal fluid and blood over the course of lymphocytic meningoradiculitis (Bannwarth's syndrome) Ann Neurol. 1986;20:337–345. doi: 10.1002/ana.410200311. [DOI] [PubMed] [Google Scholar]
  • 9.Kinnman J, Link H, Fryden A. Characterization of antibody activity in oligoclonal immunoglobulin G synthesized within the central nervous system in a patient with tuberculous meningitis. J Clin Microbiol. 1981;13:30–35. doi: 10.1128/jcm.13.1.30-35.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Klenk W, Heitmann R, Ackermann R. Rezidivlerende Erythema-Chronicum-Migrans-Krankheit des Nervensystems: Querschnittsmyelitis als Rückfall einer Meningopolyneuritis Garin-Bujadoux-Bannwarth. Aktuel Neurol. 1985;12:20–23. [Google Scholar]
  • 11.Krüger H, Englert D, Pflughaupt KW. Demonstration of oligoclonal immunglobulin G in Guillain-Barré syndrome and lymphocytic meningoradiculitis by isoelectric focusing. J Neurol. 1981;226:15–24. doi: 10.1007/BF00313314. [DOI] [PubMed] [Google Scholar]
  • 12.Link H, Laurenzi MA, Fryden A. Viral antibodies in oligoclonal and polyclonal IgG synthesized within the central nervous system over the course of mumps meningitis. J Neuroimmunol. 1981;1:287–298. doi: 10.1016/0165-5728(81)90032-1. [DOI] [PubMed] [Google Scholar]
  • 13.Magnarelli LA, Meegan JM, Anderson JF, Chappell WA. Comparison of an indirect fluorescent-antibody test with an enzyme-linked immuno-sorbent assay for serological studies of Lyme disease. J Clin Microbiol. 1984;20:181–184. doi: 10.1128/jcm.20.2.181-184.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Meyerhoff J. Lyme disease. Am J Med. 1983;75:663–670. doi: 10.1016/0002-9343(83)90454-0. [DOI] [PubMed] [Google Scholar]
  • 15.Murray N, Kristoferitsch W, Stanek G, Steck AJ. Specificity of CSF antibodies against components of Borrelia burgdorferi in patients with meningopolyneuritis Garin-Bujadoux-Bannwarth. J Neurol. 1986;233:224–227. doi: 10.1007/BF00314024. [DOI] [PubMed] [Google Scholar]
  • 16.Nordal HJ, Vandvik B, Norrby E. Demonstration of electrophoretically restricted virus-specific antibodies in serum and cerebrospinal fluid by imprint electroimmunofixation. Scand J Immunol. 1978;7:381–388. doi: 10.1111/j.1365-3083.1978.tb00468.x. [DOI] [PubMed] [Google Scholar]
  • 17.Pachner AR, Steere AC, Sigal LH, Johnson CJ. Antigen-specific proliferation of CSF lymphocytes in Lyme disease. Neurology. 1985;35:1642–1644. doi: 10.1212/wnl.35.11.1642. [DOI] [PubMed] [Google Scholar]
  • 18.Reik L, Steere AC, Bartenhagen NH, Shope RE, Malawista SE. Neurologic abnormalities of Lyme disease. Medicine. 1979;58:281–294. doi: 10.1097/00005792-197907000-00001. [DOI] [PubMed] [Google Scholar]
  • 19.Reik L, Smith L, Khan A, Nelson W. Demyelinating encephalopathy in Lyme disease. Neurology. 1985;35:267–269. doi: 10.1212/wnl.35.2.267. [DOI] [PubMed] [Google Scholar]
  • 20.Vandvik B, Nilsen RE, Vartdal F, Norrby E. Mumps meningitis: specific and non-specific antibody responses in the central nervous system. Acta Neurol Scand. 1982;65:468–484. doi: 10.1111/j.1600-0404.1982.tb03104.x. [DOI] [PubMed] [Google Scholar]
  • 21.Vandvik B, Sköldenberg B, Forsgren M, Stiernstedt G, Jeansson S, Norrby E. Long-term persistence of intrathecal virus-specific antibody responses after herpes simplex encephalitis. J Neurol. 1985;231:307–312. doi: 10.1007/BF00313707. [DOI] [PubMed] [Google Scholar]
  • 22.Vartdal F, Vandvik B, Norrby E. Intrathecal synthesis of virus-specific oligoclonal IgG, IgA and IgM antibodies in a case of varicella zoster meningoencephalitis. J Neurol Sci. 1982;57:121–132. doi: 10.1016/0022-510x(82)90116-2. [DOI] [PubMed] [Google Scholar]
  • 23.Vartdal F, Vandvik B, Michaelsen TE, Loe K, Norrby E. Neurosyphilis: intrathecal synthesis of antibodies to Treponema pallidum. Ann Neurol. 1982;11:35–40. doi: 10.1002/ana.410110107. [DOI] [PubMed] [Google Scholar]
  • 24.Weder B, Wiedersheim P, Matter L, Steck A, Otto F. Chronic progressive neurological involvement in Borrelia burgdorferi infection. J Neurol. 1987;234:40–43. doi: 10.1007/BF00314008. [DOI] [PubMed] [Google Scholar]
  • 25.Wilske B, Schierz G, Preac-Mursic V, von Busch K, Kühbeck R, Pfister H, Einhäupl K. Intrathecal production of specific antibodies against Borrelia burgdorferi in patients with lymphocytic meningoradiculitis (Bannwarth's syndrome) J Infect Dis. 1986;153:304–314. doi: 10.1093/infdis/153.2.304. [DOI] [PubMed] [Google Scholar]

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