Abstract
The 2019 novel coronavirus (2019-nCoV) is an emerging pathogen and is threatening the global health. Strikingly, more than 28 000 cases and 550 deaths have been reported within two months from disease emergence. Armed with experience from previous epidemics in the last two decades, clinicians, scientists, officials, and citizens in China are all contributing to the prevention of further 2019-nCoV transmission. Efficient preliminary work has enabled us to understand the basic characteristics of 2019-nCoV, but there are still many unanswered questions. It is too early now to judge our performance in this outbreak. Continuous and strengthened efforts should be made not only during the epidemic, but also afterwards in order to prepare for any incoming challenges.
Keywords: 2019-nCoV, novel coronavirus, epidemic, public response
Compliance with ethics guidelines
Jiuyang Xu, Yijun Chen, Hao Chen, and Bin Cao declare no conflicts of interest. This manuscript is a commentary and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.
References
- 1.China National Health Commission. The latest information for 2019 novel coronavirus infected pneumonia by Feb 5, 2020. 2020. http://www.nhc.gov.cn/xcs/yqfkdt/202002/6b1e029fd22c484281cb-c5e73dae98fc.shtml (in Chinese) (accessed February 6, 2020)
- 2.World Health Organization Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). 2020. https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-corona-virus-(2019-ncov) (accessed February 4, 2020)
- 3.Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. The Lancet. 2020;395(10223):514–523. doi: 10.1016/S0140-6736(20)30154-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. 2004. http://www.who.int/csr/sars/country/table2004_04_21/en/ (accessed February 4, 2020)
- 5.World Health Organization. Pandemic (H1N1) 2009—update 112. 2010. https://www.who.int/csr/don/2010_08_06/en/ (accessed February 4, 2020)
- 6.World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV) - Republic of Korea. 2015. https://www.who.int/csr/don/25-october-2015-mers-korea/en/ (accessed February 4, 2020)
- 7.World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV). 2019. https://www.who.int/emergencies/mers-cov/en/ (accessed February 4, 2020)
- 8.Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, Khattra J, Asano JK, Barber SA, Chan SY, Cloutier A, Coughlin SM, Freeman D, Girn N, Griffith OL, Leach SR, Mayo M, McDonald H, Montgomery SB, Pandoh PK, Petrescu AS, Robertson AG, Schein JE, Siddiqui A, Smailus DE, Stott JM, Yang GS, Plummer F, Andonov A, Artsob H, Bastien N, Bernard K, Booth TF, Bowness D, Czub M, Drebot M, Fernando L, Flick R, Garbutt M, Gray M, Grolla A, Jones S, Feldmann H, Meyers A, Kabani A, Li Y, Normand S, Stroher U, Tipples GA, Tyler S, Vogrig R, Ward D, Watson B, Brunham RC, Krajden M, Petric M, Skowronski DM, Upton C, Roper RL. The genome sequence of the SARS-associated coronavirus. Science. 2003;300(5624):1399–1404. doi: 10.1126/science.1085953. [DOI] [PubMed] [Google Scholar]
- 9.Zumla A, Chan JF, Azhar EI, Hui DS, Yuen KY. Coronaviruses—drug discovery and therapeutic options. Nat Rev Drug Discov. 2016;15(5):327–347. doi: 10.1038/nrd.2015.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Xu J, Jia W, Wang P, Zhang S, Shi X, Wang X, Zhang L. Antibodies and vaccines against Middle East respiratory syndrome coronavirus. Emerg Microbes Infect. 2019;8(1):841–856. doi: 10.1080/22221751.2019.1624482. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.Ministry of Finance of the People’s Republic of China. The government at all levels continued to increase input and allocated a total of 47 billion yuan for epidemic prevention and control. 2020. http://sbs.mof.gov.cn/gongzuodongtai/202002/t20200203_3465390.htm (in Chinese) (accessed February 4, 2020)
- 12.Zhu Na, Zhang Dingyu, Wang Wenling, Li Xingwang, Yang Bo, Song Jingdong, Zhao Xiang, Huang Baoying, Shi Weifeng, Lu Roujian, Niu Peihua, Zhan Faxian, Ma Xuejun, Wang Dayan, Xu Wenbo, Wu Guizhen, Gao George F., Tan Wenjie. A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine. 2020;382(8):727–733. doi: 10.1056/NEJMoa2001017. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9(1):221–236. doi: 10.1080/22221751.2020.1719902. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Ren L, Wang Y, Wu Z, Xiang Z, Guo L, Xu T, Jiang Y, Xiong Y, Li Y, Li H, Fan G, Gu X, Xiao Y, Gao H, Xu J, Yang F, Wang X, Wu C, Chen L, Liu Y, Liu B, Yang J, Wang X, Dong J, Li L, Huang C, Zhao J, Hu Y, Cheng Z, Liu L, Qian Z, Qin C, Jin Q, Cao B, Wang J. Identification of a novel bat-origin coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J 2020. [Epub ahead of print] doi: 10.3760/cma.j.issn.0366-6999.2020.00.E001 [DOI] [PMC free article] [PubMed]
- 15.Lu Roujian, Zhao Xiang, Li Juan, Niu Peihua, Yang Bo, Wu Honglong, Wang Wenling, Song Hao, Huang Baoying, Zhu Na, Bi Yuhai, Ma Xuejun, Zhan Faxian, Wang Liang, Hu Tao, Zhou Hong, Hu Zhenhong, Zhou Weimin, Zhao Li, Chen Jing, Meng Yao, Wang Ji, Lin Yang, Yuan Jianying, Xie Zhihao, Ma Jinmin, Liu William J, Wang Dayan, Xu Wenbo, Holmes Edward C, Gao George F, Wu Guizhen, Chen Weijun, Shi Weifeng, Tan Wenjie. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. 2020;395(10224):565–574. doi: 10.1016/S0140-6736(20)30251-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Zhou Peng, Yang Xing-Lou, Wang Xian-Guang, Hu Ben, Zhang Lei, Zhang Wei, Si Hao-Rui, Zhu Yan, Li Bei, Huang Chao-Lin, Chen Hui-Dong, Chen Jing, Luo Yun, Guo Hua, Jiang Ren-Di, Liu Mei-Qin, Chen Ying, Shen Xu-Rui, Wang Xi, Zheng Xiao-Shuang, Zhao Kai, Chen Quan-Jiao, Deng Fei, Liu Lin-Lin, Yan Bing, Zhan Fa-Xian, Wang Yan-Yi, Xiao Geng-Fu, Shi Zheng-Li. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270–273. doi: 10.1038/s41586-020-2012-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Li M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Luo Y, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JTK, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020 Jan 29. [Epub ahead of print] doi: 10.1056/NEJMoa2001316 [DOI] [PMC free article] [PubMed]
- 18.Huang Chaolin, Wang Yeming, Li Xingwang, Ren Lili, Zhao Jianping, Hu Yi, Zhang Li, Fan Guohui, Xu Jiuyang, Gu Xiaoying, Cheng Zhenshun, Yu Ting, Xia Jiaan, Wei Yuan, Wu Wenjuan, Xie Xuelei, Yin Wen, Li Hui, Liu Min, Xiao Yan, Gao Hong, Guo Li, Xie Jungang, Wang Guangfa, Jiang Rongmeng, Gao Zhancheng, Jin Qi, Wang Jianwei, Cao Bin. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 19.Chen Nanshan, Zhou Min, Dong Xuan, Qu Jieming, Gong Fengyun, Han Yang, Qiu Yang, Wang Jingli, Liu Ying, Wei Yuan, Xia Jia'an, Yu Ting, Zhang Xinxin, Zhang Li. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(10223):507–513. doi: 10.1016/S0140-6736(20)30211-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.China National Health Commission. The issuance of the diagnosis and treatment programme for pneumonia of novel coronavirus infections (pilot fifth edition) 2020. http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml (in Chinese) (accessed February 5, 2020)