Abstract
There is a growing understanding of the different syndromes that have a definite, and in some cases a possible, association with viral infections. Hepatitis C virus-associated mixed cryoglobulinemias and hepatitis B virus-associated polyarteritis nodosa are examples of a vasculitis with a definite viral association. However, various types of cutaneous vasculitis are examples of a vasculitis with only a possible association with a viral infection.
Keywords: Vasculitis, Kawasaki Disease, Varicella Zoster Virus, Polyarteritis Nodosa, Sustained Viral Response
References and Recommended Reading
- 1.Ramos-Casals M., Forns X., Brito-Zeron P., et al. Cryoglobulinaemia associated with hepatitis C virus: influence of HCV genotype, HCV-RNA viraemia and HIV coinfection. J Viral Hepatitis. 2007;14:736–742. doi: 10.1111/j.1365-2893.2007.00866.x. [DOI] [PubMed] [Google Scholar]
- 2.Gad A., Tanaka E., Matsumoto A., et al. Factors predisposing to the occurrence of cryoglobulinaemia in two cohorts of Egyptian and Japanese patients with chronic hepatitis C infection and genotypic influence. J Med Virol. 2003;70:594–599. doi: 10.1002/jmv.10435. [DOI] [PubMed] [Google Scholar]
- 3.Sansonno D., Dammaco F. Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations. Lancet Infect Dis. 2005;5:227–237. doi: 10.1016/S1473-3099(05)70053-0. [DOI] [PubMed] [Google Scholar]
- 4.Sansonno D., Lauletta G., Montrone M., et al. virologic analysis and phenotypic characterization of peripheral blood lymphocytes of hepatitis C virus-infected patients with and without mixed cryoglobulinaemia. Clin Exp Immunol. 2005;143:288–296. doi: 10.1111/j.1365-2249.2005.02987.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Saadoud D., Aaron L., Resche-Rigon M., et al. Cryoglobulinaemia vasculitis in patients coinfected with HIV and hepatitis C virus. AIDS. 2006;20:871–877. doi: 10.1097/01.aids.0000218551.62210.b5. [DOI] [PubMed] [Google Scholar]
- 6.Zhang X., Li H., Li T., et al. Distinctive rheumatic manifestations in 98 patients with HIV infection in China. J Rheumatol. 2007;34:1760–1764. [PubMed] [Google Scholar]
- 7.Cacoub P., Saadoun D., Limal N., et al. Pegylated interferon alfa-2b and ribavirin treatment in patients with hepatitis C virus-related systemic vasculitis. Arthritis Rheum. 2005;52:911–915. doi: 10.1002/art.20958. [DOI] [PubMed] [Google Scholar]
- 8.Landau D., Saadoun D., Halfon P., et al. Relapse of hepatitis C virus-associated mixed cryoglobulinaemia vasculitis with sustained viral response. Arthritis Rheum. 2008;58:604–611. doi: 10.1002/art.23305. [DOI] [PubMed] [Google Scholar]
- 9.Hurlburt K, McMahon B, Simonetti J, et al.: Hepatitis B-associated vasculitis in Alaska natives: viral genotype, clinical and serological outcome. Liver Int 2007, 627–632. [DOI] [PubMed]
- 10.Guillevin L., Maher A., Callard P., et al. Hepatitis B virusassociated polyarteritis nodosa, clinical characteristics, outcome, and impact of treatment in 115 patients. Medicine. 2005;84:313–322. doi: 10.1097/01.md.0000180792.80212.5e. [DOI] [PubMed] [Google Scholar]
- 11.Alkhatis B.A., Adler D. Cutaneous necrotising vasculitis associated with hepatitis C virus infection. Dig Dis Sci. 2007;52:3438–3439. doi: 10.1007/s10620-006-9599-x. [DOI] [PubMed] [Google Scholar]
- 12.Carlson J., Chen K. Cutaneous vasculitis update: small vessel neutrophilic vasculitis syndromes. Am J Dermatopathol. 2006;28:484–506. doi: 10.1097/01.dad.0000246646.45651.a2. [DOI] [PubMed] [Google Scholar]
- 13.Lee S., Lee K., Han J., et al. Epstein-Barr virus antibodies in Kawasaki disease. Yonsei Med J. 2006;47:475–479. doi: 10.3349/ymj.2006.47.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Dominguez S., Anderson M., Mary P., et al. Blinded casecontrol study of the relationship between human corona virus NL63 and Kawasaki syndrome. J Infect Dis. 2006;194:1697–1701. doi: 10.1086/509509. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Rowley A., Shulman S., Garcia F., et al. Cloning the arterial IgA antibody response during acute Kawasaki disease. J Immunol. 2005;175:8386–8391. doi: 10.4049/jimmunol.175.12.8386. [DOI] [PubMed] [Google Scholar]
- 16.Rowley A., Shulman S. New developments in the search for the etiologic agent of Kawasaki disease. Curr Opin Pediatr. 2007;19:71–74. doi: 10.1097/MOP.0b013e328012720f. [DOI] [PubMed] [Google Scholar]
- 17.Nagel M., Forghani B., Mahalingam R., et al. The value of detecting anti-VZV IgG antibody in the CSF to diagnose VZV vasculopathy. Neurology. 2007;68:1069–1073. doi: 10.1212/01.wnl.0000258549.13334.16. [DOI] [PubMed] [Google Scholar]