Abstract
Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N-hydroxybenzotriazole or N-hydroxysuccinimide with N,N′-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl ester exhibited antiviral activity against influenza viruses A/H3N2, A/H1N1/pdm09, A/H5N1, B (SI > 10–29), and HRSV (SI > 25). GA conjugate with D-Trp methyl ester inhibited influenza virus A/H1N1/pdm09 (SI > 30).
Keywords: glycyrrhizic acid, amino acids, conjugates, antiviral activity
Footnotes
Original Russian Text © A.I. Fayrushina, L.A. Baltina, Jr., L.A. Baltina, N.I. Konovalova, P.A. Petrova, M.Yu. Eropkin, 2017, published in Bioorganicheskaya Khimiya, 2017, Vol. 43, No. 4, pp. 427–434.
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